LEADER 03816nam 22007335 450 001 9910863146703321 005 20251113183557.0 010 $a9783030602352 010 $a3030602354 024 7 $a10.1007/978-3-030-60235-2 035 $a(CKB)4100000011508833 035 $a(DE-He213)978-3-030-60235-2 035 $a(MiAaPQ)EBC6381106 035 $a(PPN)252519132 035 $a(MiAaPQ)EBC29077974 035 $a(EXLCZ)994100000011508833 100 $a20201016d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOptical Whispering Gallery Modes for Biosensing $eFrom Physical Principles to Applications /$fby Frank Vollmer, Deshui Yu 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 417 p. 142 illus.) 225 1 $aBiological and Medical Physics, Biomedical Engineering,$x2197-5647 311 08$a9783030602345 311 08$a3030602346 327 $aFrom the Contents: Introduction: Need for label-free chip-scale clinical diagnostics and nanoparticle analyzers -- Fundamentals of photonics (light, wave, polarization, interference) -- Fundamental optical properties of biomolecules -- Light matter interaction with biomolecules (Lorentz- model, drude-model, light at a sensor interface, reflection, transmission, evanescent field) -- Physics of optical micro-resonators (fabry perot, microsphere, resonance, photonic atom model, photonic crystals, ring resonator, bottleneck resonator, microtube resonator, capillary resonator). 330 $aThis interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light?matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics. For the more advanced reader, advanced applications of WGMs and LSPRs in exploring the fundamental nature of quantum physics are discussed. . 410 0$aBiological and Medical Physics, Biomedical Engineering,$x2197-5647 606 $aBiophysics 606 $aMaterials 606 $aDetectors 606 $aBiomedical engineering 606 $aMedicinal chemistry 606 $aNanobiotechnology 606 $aBiophysics 606 $aSensors and biosensors 606 $aBiomedical Engineering and Bioengineering 606 $aMedicinal Chemistry 606 $aNanobiotechnology 615 0$aBiophysics. 615 0$aMaterials. 615 0$aDetectors. 615 0$aBiomedical engineering. 615 0$aMedicinal chemistry. 615 0$aNanobiotechnology. 615 14$aBiophysics. 615 24$aSensors and biosensors. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aMedicinal Chemistry. 615 24$aNanobiotechnology. 676 $a610.28 700 $aVollmer$b Frank$0843496 702 $aYu$b Deshui 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910863146703321 996 $aOptical whispering gallery modes for biosensing$92255290 997 $aUNINA