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010   $a981-15-6930-4
024 7 $a10.1007/978-981-15-6930-2
035   $a(CKB)4100000011526793
035   $a(MiAaPQ)EBC6381388
035   $a(DE-He213)978-981-15-6930-2
035   $a(PPN)26030087X
035   $a(EXLCZ)994100000011526793
100   $a20201024d2020      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAutophagy in tumor and tumor microenvironment /$fedited by Sujit Kumar Bhutia
205   $a1st ed. 2020.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2020.
215   $a1 online resource (VII, 280 p. 38 illus., 37 illus. in color.) 
311 08$a981-15-6929-0 
327   $aChapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy ? An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
330   $aThis book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy?s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
606   $aCancer
606   $aImmunology
606   $aMedical microbiology
606   $aMolecular genetics
606   $aStem cells
606   $aCell death
606   $aCancer Biology
606   $aImmunology
606   $aMedical Microbiology
606   $aMolecular Genetics
606   $aStem Cell Biology
606   $aCell Death
615  0$aCancer.
615  0$aImmunology.
615  0$aMedical microbiology.
615  0$aMolecular genetics.
615  0$aStem cells.
615  0$aCell death.
615 14$aCancer Biology.
615 24$aImmunology.
615 24$aMedical Microbiology.
615 24$aMolecular Genetics.
615 24$aStem Cell Biology.
615 24$aCell Death.
676   $a616.9940072
702   $aBhutia$b Sujit Kumar
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910863108703321
996   $aAutophagy in tumor and tumor microenvironment$92046991
997   $aUNINA