LEADER 01073nam a22002651i 4500 001 991000726509707536 005 20040128142829.0 008 040220s1993 it |||||||||||||||||ita 035 $ab12661272-39ule_inst 035 $aARCHE-065961$9ExL 040 $aDip.to Scienze pedagogiche$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a155.282 100 1 $aMarchesan, Rolando$0482758 245 10$aPsicologia della scrittura /$cRolando Marchesan 260 $aMilano :$bXenia,$c1993 300 $a235 p. ;$c21 cm 440 2$aI libri dell'altra scienza / collana diretta da Cesare Mariscotti 650 4$aGrafologia 907 $a.b12661272$b02-04-14$c17-03-04 912 $a991000726509707536 945 $aLE022 MP 124 F 25$g1$i2022000188135$lle022$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i13168393$z17-03-04 945 $aLE022 MP 124 F 25 bis$g2$i2022000188142$lle022$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i1316840x$z17-03-04 996 $aPsicologia della scrittura$9273095 997 $aUNISALENTO 998 $ale022$b17-03-04$cm$da $e-$fita$git $h0$i2 LEADER 02460oam 22005652 450 001 9910861081003321 005 20240513010317.0 010 $a1-000-71081-5 010 $a1-000-71003-3 010 $a0-429-27506-4 035 $a(CKB)4100000009930727 035 $a(MiAaPQ)EBC5981919 035 $a(OCoLC)1130379655 035 $a(OCoLC-P)1130379655 035 $a(FlBoTFG)9780429275067 035 $a(MiAaPQ)EBC31202573 035 $a(Au-PeEL)EBL31202573 035 $a(EXLCZ)994100000009930727 100 $a20191123d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStatistics in regulatory science /$fby Shein-Chung Chow 205 $a1st ed. 210 1$aBoca Raton :$cCRC Press,$d[2018] 215 $a1 online resource (553 pages) 225 1 $aChapman and Hall/CRC Biostatistics Series 311 $a0-367-22476-3 320 $aIncludes bibliographical references and index. 327 $aTotality-of-the-evidence -- Hypotheses testing versus confidence interval -- Endpoint selection -- Non-inferiority margin -- Missing data -- Multiplicity -- Sample size -- Reproducible research -- Extrapolation -- Consistency evaluation -- Drug products with multiple components -- Adaptive trial design -- Selection criteria in adaptive dose finding -- Generic drugs and biosimilars -- Precision and personalized medicine -- Big data analytics -- Rare disease drug development. 330 $a"The proposed book will focus on practical issues in pharmaceutical/clinical research and development from both regulatory and scientific perspectives. The book will outline and clarify those issues that have been commonly misused in the subject area of regulatory science"--$cProvided by publisher. 410 0$aChapman & Hall/CRC biostatistics series. 606 $aDrugs$xTesting 606 $aClinical trials$xStatistical methods 606 $aPharmacy$xResearch 606 $aResearch$xStatistical methods 615 0$aDrugs$xTesting. 615 0$aClinical trials$xStatistical methods. 615 0$aPharmacy$xResearch. 615 0$aResearch$xStatistical methods. 676 $a615.19 700 $aChow$b Shein-Chung$f1955-$0254512 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910861081003321 996 $aStatistics in regulatory science$94167033 997 $aUNINA