LEADER 03784nam 22005895 450 001 9910855392603321 005 20250807145458.0 010 $a981-9701-46-5 024 7 $a10.1007/978-981-97-0146-9 035 $a(MiAaPQ)EBC31318905 035 $a(Au-PeEL)EBL31318905 035 $a(CKB)31889897400041 035 $a(DE-He213)978-981-97-0146-9 035 $a(EXLCZ)9931889897400041 100 $a20240502d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances and Prospects of 3-d Metal-Based Anticancer Drug Candidates /$fby Farukh Arjmand, Sartaj Tabassum, Huzaifa Yasir Khan 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (292 pages) 311 08$a981-9701-45-7 327 $a1. Introduction -- 2. Classification of Metal-Based Anticancer Chemotherapeutic Agents -- 3. Interaction Studies of Metal-Based Anticancer Drug Entities with Potential Therapeutic Targets -- 4. Biophysical and Spectroscopic Techniques to Validate the Interaction with Therapeutic targets -- 5. DNA Condensation Processes mediated by Metal-based Drug Entities and Morphological Studies -- 6. Molecular Docking and Computational in silico Investigations of Metal-Based Drug Agents -- 7.Biochemical Mechanistic Pathway of Cell Death Induced by Metal-Based Chemotherapeutic Agents -- 8.Combination Drug Strategies for Targeting Specific Biochemical Pathways for Superior Therapeutic Potency -- 9. Advanced Drug Delivery Strategies for Metal-Based Anticancer Drugs -- 10. Endoplasmic Reticulum(ER) Targeted Metal-Based Anticancer Chemotherapeutic Agents -- 11.Progress and Future Projections in Metal-Based Polymeric Anticancer Compounds -- 12. Conclusions. 330 $aThis book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, also called necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs. 606 $aCancer$xTreatment 606 $aCancer 606 $aMetabolism 606 $aBiochemistry 606 $aCancer Therapy 606 $aCancer Metabolism 606 $aBiochemistry 615 0$aCancer$xTreatment. 615 0$aCancer. 615 0$aMetabolism. 615 0$aBiochemistry. 615 14$aCancer Therapy. 615 24$aCancer Metabolism. 615 24$aBiochemistry. 676 $a616.994061 700 $aArjmand$b Farukh$01738186 701 $aTabassum$b Sartaj$01738187 701 $aKhan$b Huzaifa Yasir$01738188 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910855392603321 996 $aAdvances and Prospects of 3-D Metal-Based Anticancer Drug Candidates$94160171 997 $aUNINA