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010   $a981-9716-66-7
024 7 $a10.1007/978-981-97-1666-1
035   $a(CKB)31988218900041
035   $a(MiAaPQ)EBC31323712
035   $a(Au-PeEL)EBL31323712
035   $a(DE-He213)978-981-97-1666-1
035   $a(EXLCZ)9931988218900041
100   $a20240506d2024      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDrug Resistance in Cancer: Mechanisms and Strategies /$fedited by Sameer Ullah Khan, Fayaz Malik
205   $a1st ed. 2024.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024.
215   $a1 online resource (0 pages)
311 08$a981-9716-65-9 
320   $aIncludes bibliographical references.
327   $a1. Introduction to Drug Resistance in Cancer -- 2. Mechanisms of Cancer Resistance to Various Therapies -- 3. Role of cancer Stem Cells in Drug Resistance -- 4. Immune cells - Critical players in Drug Resistance -- 5. Tumor Microenvironment: Multiway Role in Drug Resistance -- 6. Cancer Drug Resistance and Metabolic Reprogramming -- 7. Epigenetic alterations as an adaptive response to chemotherapy -- 8. Autophagy plays a dual role in drug resistance -- 9. Intracellular compartments and drug resistance -- 10. Gut microbes: Role in cancer and cancer drug resistance -- 11. Novel strategies for overcoming drug resistance -- 12. Future directions and challenges in overcoming drug resistance in cancer.
330   $aThis book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
606   $aCancer
606   $aCancer$xTreatment
606   $aCancer Biology
606   $aCancer Microenvironment
606   $aCancer Therapy
615  0$aCancer.
615  0$aCancer$xTreatment.
615 14$aCancer Biology.
615 24$aCancer Microenvironment.
615 24$aCancer Therapy.
676   $a616.994061
702   $aKhan$b Sameer Ullah
702   $aMalik$b Fayaz
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910855388203321
996   $aDrug Resistance in Cancer$94160130
997   $aUNINA