LEADER 04254nam 22006015 450 001 9910855385103321 005 20250807145416.0 010 $a981-9991-95-1 024 7 $a10.1007/978-981-99-9195-2 035 $a(MiAaPQ)EBC31318926 035 $a(Au-PeEL)EBL31318926 035 $a(CKB)31889903900041 035 $a(DE-He213)978-981-99-9195-2 035 $a(EXLCZ)9931889903900041 100 $a20240502d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances in Antiviral Research /$fedited by Naveen Kumar, Yashpal Singh Malik, Shailly Tomar, Sayeh Ezzikouri 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (463 pages) 225 1 $aLivestock Diseases and Management,$x2662-4354 311 08$a981-9991-94-3 327 $a1. Antivirals: approaches and the way forward -- 2. Bioinformatics databases and tools available for the development of antiviral drugs -- 3. Developments in computer-aided drug design for antiviral research -- 4. Organoids in antiviral research: potential and challenges -- 5. Metabolomics tools in antiviral research -- 6. Epigenetic- and epitranscriptomic- targeted reprogramming: novel targets for the development of broad-spectrum antivirals -- 7. Application of cryoelectron microscopy in antiviral research -- 8. Host directed antiviral therapy -- 9. Role of herbal formulations in antiviral therapy - an overview -- 10. The use of animal models for antiviral therapeutics development: opportunities and challenges -- 11. In-vitro and in-vivo evaluation tools of SARS-CoV-2 antiviral drugs -- 12. Discovery of SARS-CoV-2 antiviral drugs through large-scale virtual screening of FDA-approved drugs -- 13. A high-throughput computational pipeline for selection of effective antibody therapeutics against viruses -- 14. Insights on various antiviral drugs for treating patients with COVID- 19 -- 15. In ovo based antiviral assay for screening of herbal formulations against Influenza viruses -- 16. The path to cure Hepatitis B: How far are we? -- 17. Unveiling emerging avenues in antiviral research: navigating clinical trials and regulatory landscapes. 330 $aThis book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitable for antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers. 410 0$aLivestock Diseases and Management,$x2662-4354 606 $aVirology 606 $aDrugs$xDesign 606 $aBioinformatics 606 $aVirology 606 $aStructure-Based Drug Design 606 $aBioinformatics 615 0$aVirology. 615 0$aDrugs$xDesign. 615 0$aBioinformatics. 615 14$aVirology. 615 24$aStructure-Based Drug Design. 615 24$aBioinformatics. 676 $a615.7924 700 $aKumar$b Naveen$0510029 701 $aMalik$b Yashpal Singh$01075314 701 $aTomar$b Shailly$01738094 701 $aEzzikouri$b Sayeh$01738095 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910855385103321 996 $aAdvances in Antiviral Research$94160101 997 $aUNINA