LEADER 03858nam 22005655 450 001 9910855374003321 005 20250807143229.0 010 $a981-9708-30-3 024 7 $a10.1007/978-981-97-0830-7 035 $a(MiAaPQ)EBC31318904 035 $a(Au-PeEL)EBL31318904 035 $a(CKB)31889897200041 035 $a(DE-He213)978-981-97-0830-7 035 $a(EXLCZ)9931889897200041 100 $a20240502d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetic Studies in Model Organisms $eFrom Classical to Modern Genetics /$fby Kwang-Wook Choi 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (475 pages) 225 1 $aKAIST Research Series,$x2214-255X 311 08$a981-9708-29-X 327 $aPart I. Mendel, Genetic Models, and Mutations -- Chapter 1. Mendel's Principles of Inheritance and Chromosome Theory -- Chapter 2. Genetic Model Organisms -- Chapter 3. Recombination and Chromosomal Rearrangements -- Chapter 4. Loss-of-Function Mutagenesis in Forward Genetics -- Part II. Transposons, Transgenesis, Gene Editing, and Genetic Mosaics -- Chapter 5. Non-Mendelian Genetics: Transposable elements (I) -- Chapter 6. Transposable Elements II: Insertional Mutagenesis -- Chapter 7. Gain-of-Function and Gene Silencing -- Chapter 8. Genetic Interaction, Epistasis, Modifiers -- Chapter 9. Targeted Mutagenesis -- Chapter 10. Transgenesis in Clonal Analysis -- Part III. Epigenetics, Genome Organization, and piRNA -- Chapter 11. Epigenetic Control of Gene Expression -- Chapter 12. Chromosomal Interaction in Chromatin Organization -- Chapter 13. Piwi and piRNA in Germline and Epigenetic Regulation -- Part IV. Applications of Genetic Analysis -- Chapter 14. Genetic Control of Dosage Compensation -- Chapter 15. Genetics of Programmed Cell Death -- Chapter 16. Genetics of Growth Control -- Chapter 17. Genetic Studies on Behavior. 330 $aThis book reviews key advances and new fundamentals in genetics. The increasing importance of genetic approaches in diverse areas of biology and medical sciences constantly requires in-depth information on genetic discoveries and research strategies for advanced graduate-level students as well as current researchers. This book focuses on genetic studies of various animal model systems and their major contributions to establishing modern genetics. Information covered in this book is mostly based on original research papers that extend from classical to modern genetics and applications. The contents are organized into four parts. Part I introduces fundamental concepts and experimental strategies in classical genetics. Part II discusses molecular genetics with transposons, transgenesis, clonal analysis, and gene editing technologies. Part III emphasizes epigenetic regulation of genome organization and gene expression. Part IV integrates earlier parts with landmark genetic studies on non-coding RNAs in dosage compensation, programmed cell death, growth control related to cancer, and behavioral neurobiology. . 410 0$aKAIST Research Series,$x2214-255X 606 $aBiology 606 $aGenetics 606 $aBiological Sciences 606 $aGenetics 606 $aGenetics and Genomics 606 $aGenotype 615 0$aBiology. 615 0$aGenetics. 615 14$aBiological Sciences. 615 24$aGenetics. 615 24$aGenetics and Genomics. 615 24$aGenotype. 676 $a575.1 700 $aChoi$b Kwang-Wook$01737847 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910855374003321 996 $aGenetic Studies in Model Organisms$94159749 997 $aUNINA LEADER 02462nam 2200493 a 450 001 9910973243403321 005 20200520144314.0 010 $a0-19-803235-8 010 $a9786610481590 010 $a1-4237-6221-5 010 $a1-280-48159-5 035 $a(CKB)24235078400041 035 $a(Au-PeEL)EBL3052258 035 $a(CaPaEBR)ebr10211924 035 $a(CaONFJC)MIL48159 035 $a(OCoLC)488448232 035 $a(OCoLC)44046914 035 $a(FINmELB)ELB163047 035 $a(MiAaPQ)EBC3052258 035 $a(EXLCZ)9924235078400041 100 $a20000508d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe architecture of reason $ethe structure and substance of rationality /$fRobert Audi 210 $aOxford ;$aNew York $cOxford University Press$d2001 215 $axvi, 286 p 311 08$a0-19-514112-1 320 $aIncludes bibliographical references and index. 327 $apt. 1. Theoretical reason -- pt. 2. Practical reason -- pt. 3. Rationality and relativity. 330 $aThe literature on theoretical reason has been dominated by epistemological concerns, treatments of practical reason by ethical concerns. This book deals sets out a comprehensive theory of rationality applicable to both practical and theoretical reason. In both domains, Audi explains how experience grounds rationality, delineates the structure of central elements, and attacks the egocentric conception of rationality. He establishes the rationality of altruism and thereby supports major moral principles. The concluding part describes the pluralism and relativity his conception of rationality accommodates and, taking the unified account of theoretical and practical rationality in that light, constructs a theory of global rationality--the overall rationality of persons."Robert Audi's new book is magisterial in tone and subject matter.It displays his customary wisdom, restraint, and balanced judgement. And, like his other works, it is written impeccably, indeed elegantly."--Panayot Butchvarov, University of Iowa. 606 $aReason 615 0$aReason. 676 $a128/.33 700 $aAudi$b Robert$f1941-$0164278 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910973243403321 996 $aThe architecture of reason$94447117 997 $aUNINA