LEADER 04832nam 22005655 450 001 9910847599503321 005 20250610110425.0 010 $a981-9700-48-5 024 7 $a10.1007/978-981-97-0048-6 035 $a(CKB)31367742500041 035 $a(DE-He213)978-981-97-0048-6 035 $a(MiAaPQ)EBC31267114 035 $a(MiAaPQ)EBC31251680 035 $a(EXLCZ)9931367742500041 100 $a20240403d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAnimal Models in Research $ePrinciples and Practice /$fedited by Harikrishnan Vijayakumar Sreelatha, Satish Patel, Perumal Nagarajan 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (XV, 640 p. 308 illus., 230 illus. in color.) 311 08$a981-9700-47-7 327 $a1. The Key Concepts of Animal Models -- 2. Ethics Welfare, 3R?s & Legislation in Biomedical Research- A Practical Approach -- 3. Experimental Design and Statistics in Animal Research -- 4. New Approach Methodologies: Rethinking Preclinical Evaluation of Pharmaceuticals and Medical Devices Beyond Animal Models -- 5. Basic techniques to facilitate small animal experimentation -- 6. Zebrafish: An animal model in biomedical research -- 7. Avian Models for Biomedical Research -- 8. The naked mole-rat (Heterocephalus glaber): a promising non-traditional model for biomedical research -- 9. Pharmacologically induced Animal models for various Diseases -- 10. Animal Models for Gut Microbiome Research -- 11. Animal Model for Alzheimer?s disease, Parkinson?s disease and Schizophrenia -- 12. Animal models in sleep research -- 13. Animal Models for Pain Research -- 14. Animal models in cancer research: Revolutionizing the field of oncology -- 15. Animal models of infectious diseases -- 16. Modeling Ischemic Stroke by Middle Cerebral Artery Occlusion in Rats -- 17. Dog as an animal model in preclinical research -- 18. Swine as an animal model in preclinical research -- 19. Evaluation of Biomaterials- Histopathology Techniques Used in the Screening of Biomaterials to Ensure Biocompatibility -- 20. Methods in Toxicologic Pathology. . 330 $aThis book describes the development of animal models widely used in biomedical research using step-wise instructions and photographs. Showcasing a wide range of species from zebra fishes, birds, rodents, rabbits, dogs, and pigs, the book includes detailed methodology on how to work with these species and to develop various models. The animal models in neurology including stroke, Alzheimer?s disease, Parkinson?s disease, and Schizophrenia; Animal models in cancer research, sleep disorders, and cardiovascular diseases are described to meet the understanding of researchers who plan to replicate these models in their laboratories. In depth detailing on the development of targeted gene knockouts and transgenics, implantation models that are used in toxicology studies, and pharmacokinetic studies in pigs and dogs are a highlight. Further, the book describes pharmacologic, chemically induced, surgically induced, microbiologically induced, infectious models, models for neurobehavioral studies, oncology research, and pain research. The book has dedicated sections on anesthesia and analgesia and teaches procedures like venous cut-downs and cannulations in pigs and dogs, and endotracheal intubation, mechanical ventilation and thoracotomy in rodents and will serve as a self-training tool. Concepts in the field of animal model development are explained using examples. Sample size selection, study design, and statistical evaluation of experiments involving laboratory animals are explained to enable young researchers to practically understand the nuances. This book will be a valuable tool for academicians, students, scientists, and veterinarians and will benefit equally who are new to the field and who are already working with laboratory animals. . 606 $aVeterinary medicine 606 $aAnimal culture 606 $aBiology$xTechnique 606 $aVeterinary Science 606 $aAnimal Science 606 $aExperimental Organisms 615 0$aVeterinary medicine. 615 0$aAnimal culture. 615 0$aBiology$xTechnique. 615 14$aVeterinary Science. 615 24$aAnimal Science. 615 24$aExperimental Organisms. 676 $a616.027 700 $aVijayakumar Sreelatha$b Harikrishnan$01769754 702 $aPatel$b Satish 702 $aNagarajan$b P$g(Perumal), 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910847599503321 996 $aAnimal Models in Research$94242137 997 $aUNINA