LEADER 03731nam 22006375 450 001 9910847585003321 005 20240413124815.0 010 $a3-031-55287-3 024 7 $a10.1007/978-3-031-55287-8 035 $a(CKB)31491609400041 035 $a(MiAaPQ)EBC31276950 035 $a(Au-PeEL)EBL31276950 035 $a(DE-He213)978-3-031-55287-8 035 $a(EXLCZ)9931491609400041 100 $a20240413d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aActivation and Detoxification Enzymes$b[electronic resource] $eFunctions and Implications /$fby Chang-Hwei Chen 205 $a2nd ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (257 pages) 311 $a3-031-55286-5 327 $aOverview -- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles -- Transport and Excretion of Foreign Compounds -- Metabolic Conversion of Foreign Compounds -- Phase I Activation Enzymes -- Phase II Detoxification Enzymes -- Catalytic Reactions of Activation Enzymes -- Catalytic Reactions of Detoxification Enzymes -- Reactive Intermediates and their Interactions -- Metabolite - Associated Cell Toxicities -- Oxidative Stress and Electrophilic Stress -- Metabolic Enzymes: Polymorphism and Species Differences -- Defense Against Oxidative Stress: Nrf2-ARE Pathway -- Inducibility of Metabolic Enzymes -- Inducers of Metabolic Enzymes -- Diversified Classes of Enzyme Modulators -- Metabolite - Mediated Disease Conditions -- Metabolic Enzyme Induction for Health Benefits -- Diet Effects on Metabolic Enzymes. 330 $aThis book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. . 606 $aHuman physiology 606 $aEnzymology 606 $aPharmacology 606 $aNutrition 606 $aBioinformatics 606 $aHuman Physiology 606 $aEnzymology 606 $aPharmacology 606 $aNutrition 606 $aComputational and Systems Biology 615 0$aHuman physiology. 615 0$aEnzymology. 615 0$aPharmacology. 615 0$aNutrition. 615 0$aBioinformatics. 615 14$aHuman Physiology. 615 24$aEnzymology. 615 24$aPharmacology. 615 24$aNutrition. 615 24$aComputational and Systems Biology. 676 $a612/.0151 700 $aChen$b Chang-Hwei$01062885 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910847585003321 996 $aActivation and Detoxification Enzymes$94156192 997 $aUNINA