LEADER 04503nam  22007335  450 
001 9910847083403321
005 20251113155231.0
010   $a3-031-52864-6
024 7 $a10.1007/978-3-031-52864-4
035   $a(CKB)31253135600041
035   $a(MiAaPQ)EBC31266962
035   $a(Au-PeEL)EBL31266962
035   $a(MiAaPQ)EBC31233397
035   $a(Au-PeEL)EBL31233397
035   $a(DE-He213)978-3-031-52864-4
035   $a(EXLCZ)9931253135600041
100   $a20240329d2024      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDrug Delivery and Targeting /$fedited by Monika Schäfer-Korting, Ulrich S. Schubert
205   $a1st ed. 2024.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024.
215   $a1 online resource (408 pages)
225 1 $aHandbook of Experimental Pharmacology,$x1865-0325 ;$v284
311 08$a3-031-52863-8 
320   $aIncludes bibliographical references.
327   $aPart I. Nanoparticles and other Advanced Technologies -- Knowledge-based design of multi-functional polymer-based nanoparticles -- Stimuli-responsive non-viral nanoparticles for gene delivery -- Sustainability in drug and nano-particle processing -- Advanced formulation approaches for proteins -- Microneedles and polymer films ? delivery of peptides, proteins and nucleic acids -- Advances in vaccine delivery enhancers ? small molecules and nanomaterials -- Biodegradable long acting injectables: Platform technology and industrial challenges -- Part II. Visualization Technologies -- Visualization of Nano-carriers and Drugs in Cells and Tissue -- Characterization of drug delivery systems by transmission electron microscopy -- Part III. Target Specific Delivery -- Blood-brain barrier-crossing strategies for improved treatment of CNS disorders -- Interactions of nano-systems with immune cells and cancer cells ? a roadmap to clinical use?- Progress in ocular drug delivery: challenges and constraints -- New therapeutic options in pulmonal diseases ? sphingolipids and sphingolipid metabolism -- Molecular therapeutics for pulmonary diseases ? the need for drug targeting -- Delivery of mitochondrial RNA -- Part IV. Concerted Actions ? Thinking the Drug from the Beginning -- ATMP formulations and delivery -- Preclinical testing and approval of ATMP -- Looking to the future ? drug delivery in the prophylaxis and therapy of severe and chronic diseases.
330   $aSince the publication of the Handbook of Experimental Pharmacology Vol. 197 in 2010 there have been important advances in drug development, drug delivery and ? more recently ? drug targeting. This is in particular relevant with the new generation of drugs acting on the immune system and tumors. These are quite often accompanied by major adverse reactions. Safe therapy is, therefore, an important area of research, in particular in chronic diseases and in persons of old age. In addition, the Covid-19 pandemic has brought renewed attention to vaccinations against viral infections, and mRNA vaccines have been tested for vaccination in tumor therapy, too. Vaccine delivery has stimulated important research on carriers which may pave the way for other applications and enhance a path to e.g. CRISPR-cas therapy.
410  0$aHandbook of Experimental Pharmacology,$x1865-0325 ;$v284
606   $aPharmacy
606   $aPharmacology
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aClinical medicine$xResearch
606   $aPharmacovigilance
606   $aPharmacy
606   $aPharmacology
606   $aTranslational Research
606   $aClinical Research
606   $aDrug Safety and Pharmacovigilance
615  0$aPharmacy.
615  0$aPharmacology.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aClinical medicine$xResearch.
615  0$aPharmacovigilance.
615 14$aPharmacy.
615 24$aPharmacology.
615 24$aTranslational Research.
615 24$aClinical Research.
615 24$aDrug Safety and Pharmacovigilance.
676   $a615.6
702   $aScha?fer-Korting$b Monika
702   $aSchubert$b U$g(Ulrich),
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910847083403321
996   $aDrug delivery and targeting$9982230
997   $aUNINA