LEADER 04820nam 22007215 450 001 9910845487103321 005 20250807135555.0 010 $a3-031-39027-X 024 7 $a10.1007/978-3-031-39027-2 035 $a(MiAaPQ)EBC31224710 035 $a(Au-PeEL)EBL31224710 035 $a(DE-He213)978-3-031-39027-2 035 $a(CKB)31051550500041 035 $a(EXLCZ)9931051550500041 100 $a20240321d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Basis of Developmental and Stem Cell Regulation $eClassical Models Revised /$fby Hisato Kondoh 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (260 pages) 225 1 $aResults and Problems in Cell Differentiation,$x1861-0412 ;$v72 311 08$a3-031-39026-1 320 $aIncludes bibliographical references and index. 327 $aPart I. Somatic Cell Development from the Epiblast -- Chapter 1. The Epiblast and Pluripotent Stem Cell Lines -- Chapter 2. Different Types of Pluripotent Stem Cells Represent Different Developmental Stages -- Chapter 3. Gastrulation: Its Principles and Variations -- Chapter 4. How the Brain Develops from the Epiblast: The Node Is Not an Organizer -- Part II -- New Conceptions of Developmental Regulations -- Chapter 5. Multiple Cell Lineages Give Rise to a Cell Type -- Chapter 6. Organ Regeneration without Relying on Regeneration-Dedicated Stem Cells -- Chapter 7. Reciprocal Interactions Between the Epithelium and Mesenchyme in Oorganogenesis.-Chapter 8. The Significance of Repressive Processes in Developmental Regulation -- Part III. Transcriptional Regulation of Development -- Chapter 9. Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm -- Chapter 10. Enhancer Activation by Transcription Factors and Underlying Mechanisms -- Chapter 11. Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors. 330 $aThis book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology. Biomedical research is embarking on a new era due to new tools, which are exemplified by stem cell technologies, single-cell transcriptome analysis, and live imaging at a single-cell resolution. Publications based on cutting-edge technologies do often not provide the readers with deep biological backgrounds. This causes the risk that precious data are reduced to highly specific descriptions without sufficient biological contexts. Contemporary developmental biology on the other hand as written in many textbooks, is to a significant extent based on conceptions backdated many decades ago, and is not necessarily supported by recent findings. Yet, the prevailing classical notions tend to mislead modern biomedical researches. This book not only presents current models for developmental processes but also reinterprets and re-evaluates classic observations, thus linking classical and modern worlds of developmental biology. Spanning from molecular mechanisms to highly embryological matters it provides a bridge between these different disciplines. Written for advanced students of developmental and stem cell biology, researchers and teaching scholars, this book provides a new road map to modern developmental biology and stem cell biology. 410 0$aResults and Problems in Cell Differentiation,$x1861-0412 ;$v72 606 $aDevelopmental biology 606 $aStem cells 606 $aCell differentiation 606 $aCytology 606 $aDevelopmental genetics 606 $aEmbryology 606 $aDevelopmental Biology and Stem Cells 606 $aStem Cell Biology 606 $aCell Differentiation 606 $aCell Biology 606 $aDevelopmental Genetics 606 $aEmbryology 615 0$aDevelopmental biology. 615 0$aStem cells. 615 0$aCell differentiation. 615 0$aCytology. 615 0$aDevelopmental genetics. 615 0$aEmbryology. 615 14$aDevelopmental Biology and Stem Cells. 615 24$aStem Cell Biology. 615 24$aCell Differentiation. 615 24$aCell Biology. 615 24$aDevelopmental Genetics. 615 24$aEmbryology. 676 $a571.835 700 $aKondoh$b H.$01768688 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910845487103321 996 $aMolecular Basis of Developmental and Stem Cell Regulation$94231320 997 $aUNINA