LEADER 10664nam 22004933 450 001 9910842289403321 005 20240308084504.0 010 $a981-9927-18-8 035 $a(CKB)30597535100041 035 $a(MiAaPQ)EBC31200706 035 $a(Au-PeEL)EBL31200706 035 $a(MiAaPQ)EBC31203805 035 $a(Au-PeEL)EBL31203805 035 $a(EXLCZ)9930597535100041 100 $a20240308d2024 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEssentials of Veterinary Immunology and Immunopathology 205 $a1st ed. 210 1$aSingapore :$cSpringer,$d2024. 210 4$d©2024. 215 $a1 online resource (660 pages) 311 $a981-9927-17-X 327 $aIntro -- Foreword -- Contents -- About the Authors -- 1: Basic Concepts in Immunology -- 1.1 Natural or Paraspecific Immunity -- 1.2 Acquired or Specific Immunity -- 1.3 Humoral Immunity -- 1.3.1 Immunoglobulin G (IgG) -- 1.3.2 Immunoglobulin M (IgM) -- 1.3.3 Immunoglobulin A (IgA) -- 1.3.4 Immunoglobulin E (IgE) -- 1.3.5 Immunoglobulin D (IgD) -- 1.4 Cell-Mediated Immunity -- 1.5 Immune Response -- 1.6 Cells of the Immune System -- 1.6.1 Lymphoid Channel -- 1.6.2 Myeloid Channel -- 1.6.2.1 Lymphoid Cells -- T-Lymphocytes -- B-Lymphocytes -- Natural Killer Cells -- 1.6.2.2 Mononuclear Phagocytes -- Antigen-Presenting Cells -- 1.6.2.3 Polymorphonuclear Granulocytes -- 1.6.2.4 Neutrophils -- 1.6.2.5 Eosinophils -- 1.6.2.6 Basophils and Mast Cells -- 1.6.2.7 Platelets -- 1.7 Cytokines -- 1.7.1 Interferons -- 1.7.2 Interleukins -- 1.7.2.1 Interleukin-1 (IL-1) -- 1.7.2.2 Interleukin-2 (IL-2) -- 1.7.2.3 Interleukin-3 (IL-3) -- 1.7.2.4 Interleukin-4 (IL-4) -- 1.7.2.5 Interleukin-5 (IL-5) -- 1.7.2.6 Interleukin-6 (IL-6) -- 1.7.2.7 Interleukin-7 (IL-7) -- 1.7.2.8 Interleukin-8 (IL-8) -- 1.7.2.9 Interleukin-10 (IL-10) -- 1.7.2.10 Interleukin-11 (IL-11) -- 1.7.2.11 Interleukin-12 (IL-12) -- 1.7.2.12 Interleukin-13 (IL-13) -- 1.7.2.13 Interleukin-14 (IL-14) -- 1.7.2.14 Interleukin-15 (IL-15) -- 1.7.2.15 Interleukin-16 (IL-16) -- 1.7.2.16 Interleukin-17 (IL-17) -- 1.7.2.17 Interleukin-18 (IL-18) -- 1.7.3 Tumor Necrosis Factor (Cytotoxins) -- 1.7.4 Colony-Stimulating Factor -- 1.7.4.1 Macrophage Colony-Stimulating Factor -- 1.7.4.2 Granulocyte Colony-Stimulating Factor -- 1.7.4.3 Granulocyte-Monocyte Colony-Stimulating Factor -- 1.7.5 Migration Inhibitory Factor -- 1.7.5.1 Mechanism of Action -- 1.7.5.2 Historical Milestones -- Further Reading -- 2: Biomarkers of Immunopathology in Veterinary Medicine -- 2.1 Introduction. 327 $a2.2 Specific Cells of the Innate Immune System -- 2.2.1 Neutrophils -- 2.2.2 Monocytes -- 2.2.3 Lymphocytes -- 2.3 Receptors for Microbial Ligands -- 2.3.1 Transmembrane PRRs -- 2.3.2 Cytosolic PRRs -- 2.4 Inflammatory Mediators -- 2.4.1 Cytokines -- 2.4.2 Interleukins -- 2.4.3 Chemokines -- 2.5 Anti-microbial Molecules -- 2.5.1 Complement -- 2.5.2 Lysozyme -- 2.5.3 Anti-microbial Peptides -- 2.5.4 Cathelicidins -- 2.5.5 Defensins -- 2.5.6 Collectins -- 2.6 Conclusion -- References -- 3: Hypersensitivity -- 3.1 Hypersensitivity -- 3.2 Type I Hypersensitivity -- 3.2.1 Components of Type I Hypersensitivity -- 3.2.1.1 Mast Cells and Basophils -- 3.2.1.2 Immunoglobulin E (IgE) -- IgE Binding Fc Receptors -- Molecular Mechanism of IgE-Mediated Degranulation -- Intracellular Events -- 3.2.2 Mediators of Type I Hypersensitivity Reaction -- 3.2.2.1 Primary Mediators -- 3.2.2.2 Secondary Mediators -- Cytokines -- 3.2.3 Clinical Manifestations -- 3.2.3.1 Acute Systemic Anaphylaxis -- Cattle -- Sheep -- Horse -- Pig -- Dogs and Cats -- 3.2.3.2 Localized Specific Allergic Conditions -- Milk Allergy -- Food Allergy -- Respiratory Allergy -- Cattle -- Equines -- 3.2.3.3 Allergies to Parasitic Antigens in Animals -- 3.2.3.4 Drugs and Vaccine Allergies -- 3.2.4 Detection of Type I Hypersensitivity -- 3.3 Type II Hypersensitivity -- 3.3.1 Mechanism of Type II Hypersensitivity -- 3.3.1.1 Blood Groups and Hemolytic Disease -- Dog -- Cattle -- Horse -- Sheep and Goat -- Pig -- Cat -- 3.3.1.2 Hemolytic Disease of the Newborn in Humans -- 3.3.1.3 Blood Transfusion Reactions -- Blood Groups and Transfusion Reaction in Human -- 3.3.2 Type II Hypersensitivity to Drugs -- 3.3.3 Type II Hypersensitivity in Infectious Diseases -- 3.4 Type III Hypersensitivity -- 3.4.1 Serum Sickness -- 3.4.2 Autoimmune Complex Disease -- 3.4.3 Arthus Reaction. 327 $a3.4.4 Diseases Associated with Immune Complexes -- 3.4.4.1 Glomerulonephritis -- 3.4.5 Pathogenesis -- 3.4.5.1 Sub-epithelial -- 3.4.5.2 Sub-endothelial -- 3.4.5.3 Intramembranous -- 3.4.5.4 Mesangium -- 3.4.6 Clinical Findings -- 3.4.7 Lesions -- 3.4.7.1 Proliferative Glomerulonephritis -- 3.4.7.2 Membranous Glomerulonephritis -- 3.4.7.3 Membranoproliferative Glomerulonephritis -- 3.4.7.4 Mesangiosclerotic Glomerulonephritis -- 3.4.7.5 Rheumatoid Arthritis -- 3.5 Type IV Hypersensitivity -- 3.5.1 The Tuberculin Reaction -- 3.5.1.1 Mechanism of DTH Reaction -- 3.5.1.2 Mediators of DTH Response -- 3.5.1.3 Protective and Pathological Role of DTH Responses -- 3.5.2 Johnin Reaction -- 3.5.3 Other Intracellular Pathogens Showing DTH -- 3.5.4 Allergic Contact Dermatitis -- 3.5.5 Detection of Type IV Hypersensitivity -- Further Reading -- 4: Autoimmunity -- 4.1 General Concept -- 4.2 Mechanism of Induction -- 4.2.1 Physiological Autoimmunity -- 4.2.2 Pathological Autoimmunity -- 4.2.2.1 Release of Sequestered or Hidden Antigens -- 4.2.2.2 Antigens Generated by Molecular Changes -- 4.2.2.3 Molecular Mimicry -- 4.2.2.4 Inappropriate Expression of MHC Class II Molecules -- 4.2.2.5 Virus-Induced Autoimmunity -- 4.2.2.6 Genetic Factor -- 4.2.2.7 Polyclonal B-Cell Activation -- 4.2.2.8 Failure of Regulatory Control -- 4.2.3 Mechanisms of Tissue Injury -- 4.2.3.1 Complement-Mediated Lysis (Type II Hypersensitivity) -- 4.2.3.2 Immune Complex-Mediated Injuries (Type III Hypersensitivity) -- 4.2.3.3 Effector Cell-Mediated Lysis (Type IV Hypersensitivity) -- 4.3 Autoimmune Diseases -- 4.3.1 Systemic Autoimmune Diseases -- 4.3.1.1 Systemic Lupus Erythematosus (SLE) -- Pathogenesis -- Autoantigens in SLE -- Clinical Signs -- Diagnosis -- Antinuclear Antibody (ANA) Tests -- LE Cell Test -- Direct Immunofluorescence Test of Skin (Lupus Band Test). 327 $a4.3.1.2 Sjogren´s Syndrome -- 4.3.1.3 Arthritides -- 4.3.1.4 Rheumatoid Arthritis -- Pathogenesis -- Clinical Signs -- Clinical Pathology -- Pathology -- Diagnosis -- 4.3.1.5 Organ-Specific Autoimmune Diseases -- 4.3.1.6 Autoimmune Hemolytic Anemia -- Pathogenesis -- Clinical Signs -- Clinical Pathology -- Pathology -- Diagnosis -- 4.3.1.7 Autoimmune Thrombocytopenia -- Pathogenesis -- Clinical Signs -- Pathology -- Diagnosis -- 4.3.1.8 Autoimmune Endocrine Diseases -- Autoimmune Thyroiditis -- Autoimmune Thyroiditis in Chickens -- Insulin-Dependent Diabetes Mellitus -- Addition´s Disease (Autoimmune Adrenalitis) -- 4.3.1.9 Autoimmune Dermatologic Diseases -- The Pemphigus Complex -- Bullous Pemphigoid -- 4.3.1.10 Autoimmune Neuromuscular Disorders -- Myasthenia Gravis -- Pathogenesis -- Clinical Signs -- Pathology -- Diagnosis -- Polymyositis -- Autoimmune Masticatory Myopathy -- 4.3.2 Autoimmune Ocular Disease -- 4.3.2.1 Periodic Ophthalmia -- References -- Further Reading -- 5: Immunodeficiency -- 5.1 Immunodeficiency -- 5.1.1 Congenital Immunodeficiency -- 5.1.1.1 Severe Combined Immunodeficiency Syndrome -- 5.1.1.2 Defects in T-Lymphocytes -- 5.1.1.3 Defects in B-Lymphocytes -- 5.1.1.4 Partial Defects in T- and B-Lymphocytes -- 5.1.1.5 Deficiency of Complement -- 5.1.1.6 Defects in Phagocytosis -- 5.1.2 Acquired Immunodeficiency -- 5.1.2.1 Drugs -- 5.1.2.2 Infections -- 5.1.2.3 Trauma or Surgery -- 5.1.2.4 Environmental Pollution -- 5.2 Diagnosis of Immunodeficiency -- Further Reading -- 6: Immunomodulation -- 6.1 Immunomodulation -- 6.2 Need of Immunomodulation -- 6.3 Physiological Products -- 6.3.1 Neuroendocrine Hormones -- 6.4 Neuropeptides -- 6.5 Growth Hormone and Prolactin -- 6.6 Opioid Peptides -- 6.7 Thymic Products -- 6.8 Cytokines -- 6.9 Microbial Products -- 6.9.1 P. acnes (Corynebacterium Parvum) -- 6.10 Lentinan -- 6.11 Probiotics. 327 $a6.12 Chemical Compounds -- 6.12.1 Levamisole -- 6.12.2 Thiabendazole -- 6.12.3 Imuthiol -- 6.12.4 Isoprinosine -- 6.12.5 Indomethacin -- 6.12.6 Ascorbic Acid Derivatives -- 6.12.7 Dihydroheptaprenol -- 6.13 Adjuvants -- 6.14 Herbal Products -- 6.15 Vitamins -- 6.16 Cow Therapy -- References -- 7: Immunopathology of Pneumonia in Animals -- 7.1 Introduction -- 7.2 Ruminants -- 7.3 Mycoplasmal Diseases -- 7.4 Peste des Petits Ruminants (PPR) -- 7.5 Chlamydiosis -- 7.6 Parainfluenza-3 -- 7.7 Equines -- 7.8 Swine -- 7.9 Porcine Reproductive and Respiratory Syndrome (PRRS) -- 7.10 Swine Influenza -- 7.11 Other Diseases -- 7.12 Small Animals -- 7.13 Immunity to Pneumonia -- 7.14 Innate Immunity -- 7.15 Adaptive Immunity -- 7.15.1 Humoral Immunity -- 7.16 Cell-Mediated Immunity -- 7.17 Immunodeficiency in Animals -- 7.17.1 Congenital Immunodeficiency -- 7.17.1.1 Combined Immunodeficiency Syndrome -- 7.17.1.2 Defects in T- and B-Lymphocytes -- 7.17.1.3 Deficiency of Complement -- 7.17.2 Acquired Immunodeficiency -- 7.18 Immunomodulation -- 7.19 Evasion Strategies of Microbes -- 7.20 Evasion from Innate Immune Responses -- 7.20.1 Interference with the Physical Barrier -- 7.20.2 Interference with Phagocytosis by Predisposing Factors and Pathogens -- 7.20.3 Effects of Predisposing Factors and Pathogens on the Production of Innate Defense Molecules -- 7.20.4 Effects on Receptors on the Surface of Airway Epithelial Cells and Cell Signal Transduction -- 7.20.5 Interference with Intracellular Killing -- 7.20.6 Interference with IFN System -- 7.21 Evasion of Adaptive Immune Response -- 7.21.1 Infection of Leukocytes and Suppression of Proliferation -- 7.21.2 Suppression of Proliferation of Leukocytes -- 7.21.3 Infection of Cells of the Immune System -- 7.21.4 Induction of Humoral and Cellular Immune Tolerance -- 7.21.5 Inhibition of Antibody Activity. 327 $a7.21.6 Interference with Cytotoxic T-Lymphocyte Response. 676 $a636.0896079 700 $aChauhan$b Ramswaroop Singh$01732571 701 $aMalik$b Yashpal Singh$01075314 701 $aSaminathan$b M$01732572 701 $aTripathi$b Bhupendra Nath$01732573 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910842289403321 996 $aEssentials of Veterinary Immunology and Immunopathology$94146943 997 $aUNINA