LEADER 02923nam 22005653 450 001 9910842263503321 005 20250905110031.0 010 $a9781040024959 010 $a1040024955 010 $a9781040025000 010 $a1040025005 035 $a(CKB)5600000000812035 035 $a(MiAaPQ)EBC31281988 035 $a(Au-PeEL)EBL31281988 035 $a(MiAaPQ)EBC31281987 035 $a(Au-PeEL)EBL31281987 035 $a(OCoLC)1430657890 035 $a(ODN)ODN0011069995 035 $a(NjHacI)995600000000812035 035 $a(EXLCZ)995600000000812035 100 $a20240422d2024 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFlipons $eThe Discovery of Z-DNA and Soft-Wired Genomes 205 $a1st ed. 210 1$aMilton :$cTaylor & Francis Group,$d2024. 210 4$dİ2024. 215 $a1 online resource (287 pages) 311 08$a9781032731087 311 08$a1032731087 327 $aCover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Acknowledgements -- About the Author -- Part I -- Chapter 1 The Dawn -- What Is DNA? -- In the Beginning -- Chapter 2 Even Smart People Are Sometimes Wrong -- The First Sighting of Left-handed Z-DNA -- Chapter 3 Coming to America -- Chapter 4 From One Unknown to Another -- Chapter 5 Failing Successfully Everywhere Else: The In-between Years -- The Framingham Years -- The Merck Experience -- Chapter 6 How Do You Know It's You? The Answer Lies in Your Z-RNA -- Chapter 7 Can Left-handed Z-DNA and Z-RNA Kill You? -- Chapter 8 Does Z-DNA Regulate Transcription? -- Chapter 9 Luck and the Business of Science -- Part II -- Chapter 10 What about Other Types of Flipons? -- Other Types of Flipons -- G-flipons -- T-flipons -- L-flipons -- Chapter 11 Is Your Genome Soft-wired? -- Shaping DNA with RNA -- Chapter 12 How Do You Assemble a Soft-wired Genome? -- Peptide Patches -- Peptide Patches and Evolution -- Chapter 13 How Do You Program a Soft-wired Genome? -- Chapter 14 Is Life Intransitive? -- Chapter 15 Are RNA Therapeutics the Wave of the Future? -- Epilogue: Why Have a Career in Science? -- References -- Index. 330 $aAlan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. 606 $aGenomics 606 $aGene mapping 606 $aGenomes 615 0$aGenomics. 615 0$aGene mapping. 615 0$aGenomes. 676 $a572.86 700 $aHerbert$b Alan$01852698 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910842263503321 996 $aFlipons$94448580 997 $aUNINA