LEADER 05564nam 22006975 450 001 9910841871403321 005 20240312122712.0 010 $a9783031497445$b(electronic bk.) 010 $z9783031497438 024 7 $a10.1007/978-3-031-49744-5 035 $a(MiAaPQ)EBC31176083 035 $a(Au-PeEL)EBL31176083 035 $a(DE-He213)978-3-031-49744-5 035 $a(CKB)30507130900041 035 $a(EXLCZ)9930507130900041 100 $a20240222d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRegenerative Medicine and Brain Repair /$fedited by Philip V. Peplow, Bridget Martinez, Thomas A. Gennarelli 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (349 pages) 225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v75 311 08$aPrint version: Peplow, Philip V. Regenerative Medicine and Brain Repair Cham : Springer International Publishing AG,c2024 9783031497438 320 $aIncludes bibliographical references and index. 327 $aInitiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms -- Strategies to Upgrade the Stem Cell Application for Brain Transplantation -- Neural Stem Cell Intervention in Traumatic Brain Injury -- Neurotrophic Factors in Parkinson?s Disease: Clinical Trials -- Emerging Nanotechnology for the Treatment and Diagnosis of Parkinson?s Disease (PD) and Alzheimer?s Disease (AD) -- Poly(Butyl Cyanoacrylate) Nanoparticles deliver ?-Nerve Growth Factor to the Brain after Traumatic Brain Injury -- The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine -- Endogenous in situ Tissue Regeneration using Inductive Bioscaffolds after Acute Brain Injury -- Alginate Nanofibre Scaffolds for Amyotrophic Lateral Sclerosis -- Developing High-Fidelity in vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials -- Challenges and Future Perspectives of Using Bioactive Scaffolds in Brain Repair. 330 $aThis book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease. Development of effective treatments dramatically improves the independent living and quality of life of patients. Cell transplantation strategies offer an approach to facilitating brain repair, but efficacy is often limited by low in vivo survival rates of cells that are injected in suspension. Transplanting cells that are attached to or encapsulated within a biomaterial construct has the advantage of maintaining cell-cell and cell-material interactions and improving cell survival in vivo. Biomaterials that have been used in preclinical studies to assist with in vivo cell transfer and survival include heparin-chitosan microspheres, poly(lactic-co-glycolic acid) microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine ethyl ester carbonate) microscale scaffolds, carbon nanotubes, collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns with an extracellular matrix interior. Incorporating growth factors (e.g., glial-derived neurotrophic factor, neurotrophin 3) into the biomaterial constructs increased cell survival and incorporation into the host tissue. International experts in the fields of both experimental and clinical neurological research contribute chapters to this book and discuss the latest achievements in cell transplantation and matrix-assisted cell transfer/survival technologies for diseases such as Alzheimer?s disease, Parkinson?s disease, and brain injuries such as stroke and traumatic brain injury. It is envisaged that research findings in experimental animal models of Alzheimer?s disease, Parkinson?s disease, traumatic brain injury, and stroke promote clinical trials using biomaterial-assisted transfer of cells. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v75 606 $aNervous system$xRegeneration 606 $aRegenerative medicine 606 $aStem cells 606 $aBiomedical engineering 606 $aBiomaterials 606 $aRegeneration and Repair in the Nervous System 606 $aRegenerative Medicine and Tissue Engineering 606 $aStem Cell Biology 606 $aBiomedical Engineering and Bioengineering 606 $aBiomaterials 615 0$aNervous system$xRegeneration. 615 0$aRegenerative medicine. 615 0$aStem cells. 615 0$aBiomedical engineering. 615 0$aBiomaterials. 615 14$aRegeneration and Repair in the Nervous System. 615 24$aRegenerative Medicine and Tissue Engineering. 615 24$aStem Cell Biology. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aBiomaterials. 676 $a616.8 702 $aPeplow$b Philip$g(Philip V.), 702 $aMartinez$b Bridget 702 $aGennarelli$b Thomas A. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910841871403321 996 $aRegenerative Medicine and Brain Repair$94140114 997 $aUNINA