LEADER 03418nam 2200613Ia 450 001 9910841713703321 005 20230331005421.0 010 $a1-282-34760-8 010 $a9786612347603 010 $a0-470-51377-2 010 $a0-470-51378-0 035 $a(CKB)1000000000377201 035 $a(EBL)470474 035 $a(OCoLC)609849386 035 $a(SSID)ssj0000290049 035 $a(PQKBManifestationID)11211084 035 $a(PQKBTitleCode)TC0000290049 035 $a(PQKBWorkID)10404397 035 $a(PQKB)11245463 035 $a(MiAaPQ)EBC470474 035 $a(EXLCZ)991000000000377201 100 $a19890126d1989 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe Biology of hyaluronan$b[electronic resource] /$f[editors: David Evered and Julie Whelan.] 210 $aChichester, UK ;$aNew York $cWiley$d1989 215 $a1 online resource (312 p.) 225 1 $aCiba Foundation symposium ;$v143 300 $aBased on a "Symposium on the Biology of Hyaluronan, held at the Ciba Foundation, London, 27-29 September 1988." 311 $a0-471-92305-2 320 $aIncludes bibliographies and index. 327 $aTHE BIOLOGY OF HYALURONAN; Contents; Participants; Introduction; Secondary structures in hyaluronan solutions: chemical and biological implications; Identification and regulation of the eu karyotic hyaluronate synthase; Turnover and metabolism of hyaluronan; Enzymic pathways of h yal u ronan catabolism; The interaction of hyaluronate with the cell surface: the hyalu ronate receptor and the core protein; H yaluronan and hyalu ronan- binding proteins in cartilaginous tissues; The role of a cell-associated hyaluronan- binding protein in fibroblast behaviour 327 $aHyaluronate-cell interactions and growth factor regulation of hyaluronate synthesis during limb developmentThe role and tu rnou r-assoc regulation of ated hyaluronan; Interactions between cells of the immune system and hyaluronate synthesis by human dermal fibroblasts; Hyaluronan and angiogenesis; Hyaluronan and hyaluronectin in the nervous system; Changes in hyaluronan concentration in tissues and body fluids in disease states; The specific interaction between fibrin(ogen) and hyaluronan: possible consequences in haemostasis, inflammation and wound he; Clinical uses of hyaluronan 327 $aGeneral discussionsumming-UP; Index of contributors; Subject index 330 $aPresents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system. 410 0$aCiba Foundation symposium ;$v143. 606 $aHyaluronic acid$xPhysiological effect 606 $aPhysiology 615 0$aHyaluronic acid$xPhysiological effect. 615 0$aPhysiology. 676 $a591.19254 676 $a616.994071 701 $aEvered$b David$0857127 701 $aWhelan$b Julie$0322651 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910841713703321 996 $aThe Biology of hyaluronan$94144871 997 $aUNINA