LEADER 05430nam 2200661Ia 450 001 9910841416003321 005 20230607214048.0 010 $a1-280-54174-1 010 $a9786610541744 010 $a0-471-46072-9 010 $a0-471-22044-2 035 $a(CKB)111087027122382 035 $a(EBL)210521 035 $a(OCoLC)475918937 035 $a(SSID)ssj0000248429 035 $a(PQKBManifestationID)11218937 035 $a(PQKBTitleCode)TC0000248429 035 $a(PQKBWorkID)10201729 035 $a(PQKB)11451976 035 $a(MiAaPQ)EBC210521 035 $a(EXLCZ)99111087027122382 100 $a20010308d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSolid support oligosaccharide synthesis and combinatorial carbohydrate libraries$b[electronic resource] /$fedited by Peter H. Seeberger 210 $aNew York $cWiley-Interscience$dc2001 215 $a1 online resource (321 p.) 300 $aDescription based upon print version of record. 311 $a0-471-37828-3 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Contributors; 1 Solid-Phase Carbohydrate Synthesis: The Early Work; 1.1 Introduction; 1.2 Solid-Phase Strategies; 1.3 Oligosaccharide Synthesis on Soluble Polymers; 1.4 The Period of Stagnancy (1976-1991); 2 The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates; 2.1 Introduction; 2.2 Why Glycal Assembly? Strategic Considerations; 2.3 Linker Design; 2.4 Solid Support Glycal Assembly via 1,2-Anhydrosugar Donors; 2.5 Solid-Phase Synthesis of the Blood Group H Determinant; 2.6 Solid Support Glycal Assembly via Thioethyl Glycosyl Donors 327 $a2.7 Solid Support Assembly via Thioethyl 2-Amidoglycosyl Donors2.8 Solid-Phase Synthesis of the Lewis[sub(b)] Blood Group Determinant; 2.9 Solid-Phase Synthesis of the Hexasaccharide Globo-H Antigen: Progress and Limitations; 2.10 Solid-Phase Synthesis of N-Linked Glycopeptides; 2.11 Conclusions; 3 The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries; 3.1 Introduction; 3.2 Synthesis of Sulfoxide Donors; 3.3 Mechanism of the Sulfoxide Glycosylation; 3.4 Stereoselectivity 327 $a3.5 Solid-Phase Oligosaccharide Synthesis3.6 Libraries of Oligosaccharides; 3.7 Outlook; 4 The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides; 4.1 Introduction; 4.2 Polystyrene-Based Supports; 4.3 Controlled-Pore Glass as a Solid Support; 4.4 Soluble Polymers as Supports; 4.5 Oligosaccharide Syntheses on Peptides Attached to a Solid Support; 4.6 Conclusions and Outlook; 5 Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides; 5.1 Introduction; 5.2 Thioglycosides as Glycosyl Donors 327 $a5.3 Pentenyl Glycosides as Glycosyl Donors6 Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates; 6.1 Introduction; 6.2 Glycosyl Phosphate Donors; 6.3 Other Phosphorous(V) Glycosyl Donors; 6.4 Conclusion; 7 Stereoselective ?-Mannosylation on Polymer Support; 7.1 p-Methoxybenzyl-Assisted Intramolecular Aglycon Delivery: Highly Efficient ?-mannosylation; 7.2 Intramolecular Aglycon Delivery on Polymer Support: Gatekeeper-Controlled Glycosylation; 7.3 Conclusions; 8 Tools for ""On-Bead"" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis; 8.1 Introduction 327 $a8.2 IR Spectroscopic Methods8.3 NMR Spectroscopic Methods; 9 Polyethyleneglycol ?-Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides; 9.1 Introduction; 9.2 Polyethyleneglycol ?-Monomethylether (MPEG); 9.3 Linkers; 9.4 MPEG-Supported Syntheses Using Enzymes; 9.5 Use of MPEG in Mechanistic Studies; 9.6 MPEG and Combinatorial Libraries; 9.7 Other Applications; 9.8 Capping; 9.9 Outlook; 10 Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides; 10.1 Two-Directional Glycosylations in Solution 327 $a10.2 Two-Directional Glycosylations on Solid Support 330 $aSolid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.With ch 606 $aOligosaccharides$xSynthesis 606 $aGlycoconjugates 606 $aCombinatorial chemistry 606 $aSolid-phase synthesis 615 0$aOligosaccharides$xSynthesis. 615 0$aGlycoconjugates. 615 0$aCombinatorial chemistry. 615 0$aSolid-phase synthesis. 676 $a547.7815 676 $a572/.565 701 $aSeeberger$b Peter H.$f1966-$01730143 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910841416003321 996 $aSolid support oligosaccharide synthesis and combinatorial carbohydrate libraries$94140792 997 $aUNINA