LEADER 05422nam 2200709Ia 450 001 9910841275203321 005 20230607213145.0 010 $a1-280-36661-3 010 $a9786610366613 010 $a0-470-34865-8 010 $a0-471-46106-7 010 $a0-471-22388-3 035 $a(CKB)111056485579848 035 $a(EBL)468979 035 $a(OCoLC)52400037 035 $a(SSID)ssj0000261261 035 $a(PQKBManifestationID)11191975 035 $a(PQKBTitleCode)TC0000261261 035 $a(PQKBWorkID)10255822 035 $a(PQKB)10341944 035 $a(MiAaPQ)EBC468979 035 $a(EXLCZ)99111056485579848 100 $a20000630d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranscription factors$b[electronic resource] $enormal and malignant development of blood cells /$fedited by Katya Ravid, Jonathan Licht 210 $aNew York $cWiley-Liss$dc2001 215 $a1 online resource (642 p.) 300 $aIncludes bibliographical references and index. 300 $aIncludes index. 311 $a0-471-35054-0 327 $aTRANSCRIPTION FACTORS; CONTENTS; Introduction; Contributors; I TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES; 1 The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation; 2 Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2; 3 Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis; 4 Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis; 5 EKLF and the Development of the Erythroid Lineage; II TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE 327 $a6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages7 PU.1 and the Development of the Myeloid Lineage; 8 CCAAT/Enhancer-Binding Proteins in Myeloid Cells; 9 Homeobox Gene Networks and the Regulation of Hematopoiesis; 10 The Role of Retinoic Acid Receptors in Myeloid Differentiation; 11 Transcriptional Targets of the Vitamin D(3) Receptor During Myeloid Cell Differentiation; III TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE; 12 The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation 327 $a13 The Role of PU.1 in B-Lymphocyte Development and Function14 The Role of Pax5 (BSAP) in Early and Late B-Cell Development; 15 Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells; 16 E2A and the Development of B and T Lymphocytes; 17 The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas; 18 The Role of Octamer Factors and Their Coactivators in the Lymphoid System; 19 The Role of Early B-Cell Factor in B-Lymphocyte Development; IV. TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION 327 $a20 The Role of RARa and Its Fusion Partners in Acute Promyelocytic Leukemia21 The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11; 22 EVI1 Rearrangements in Malignant Hematopoiesis; 23 t(8; 21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemia; 24 TEL/ETV6 Gene Rearrangements in Human Leukemias; 25 MLL in Normal and Malignant Hematopoiesis; 26 Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL; 27 The LMO2 Master Gene 327 $aIts Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis28 The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations; V. ONCOGENESIS AND HEMATOPOIESIS; 29 The Roles of the c-myc and c-myb Oncogenes in Hematopoiesis and Leukemogenesis; 30 NF-kB in Cell Life and Death; VI. SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES; 31 Transcription Factors Implicated in Hematopoiesis: In Vivo Studies 327 $a32 Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma 330 $aThe role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the 606 $aHematopoiesis 606 $aGenetic regulation 606 $aLeukemia$xGenetic aspects 606 $aTranscription factors 606 $aGenetic transcription 615 0$aHematopoiesis. 615 0$aGenetic regulation. 615 0$aLeukemia$xGenetic aspects. 615 0$aTranscription factors. 615 0$aGenetic transcription. 676 $a612.1/1 676 $a616.15 701 $aRavid$b Katya$01728843 701 $aLicht$b Jonathan D$01728844 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910841275203321 996 $aTranscription factors$94138151 997 $aUNINA