LEADER 05427nam 2200685Ia 450 001 9910841169403321 005 20210209220459.0 010 $a1-281-08786-6 010 $a1-282-13982-7 010 $a9786612139826 010 $a9786611087869 010 $a3-527-60931-8 010 $a3-527-60929-6 035 $a(CKB)1000000000377321 035 $a(EBL)482046 035 $a(OCoLC)160074602 035 $a(SSID)ssj0000178782 035 $a(PQKBManifestationID)11156252 035 $a(PQKBTitleCode)TC0000178782 035 $a(PQKBWorkID)10229822 035 $a(PQKB)10867331 035 $a(MiAaPQ)EBC482046 035 $a(MiAaPQ)EBC4957014 035 $a(Au-PeEL)EBL4957014 035 $a(CaONFJC)MIL108786 035 $a(OCoLC)815537102 035 $a(PPN)199223866 035 $a(EXLCZ)991000000000377321 100 $a20050110d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aInfections causing human cancer /$fHarald zur Hausen ; with a contribution of James G. Fox, Timothy C. Wang and Julie Parsonnet 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley [distributor]$dc2006 215 $a1 online resource (533 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31056-8 320 $aIncludes bibliographical references and index. 327 $aInfections Causing Human Cancer; Table of Contents; Preface; 1 Historical Review; 1.1 The Early Period (1898-1911); 1.2 Frustration and Successes (1912-1950); 1.3 The Period from 1950 to 1965; 1.4 A First Human Tumorvirus?; 1.5 The Difficult 1970s; 1.6 The Re-Emergence of a Concept; References; 2 The Quest for Causality; 2.1 Infectious Agents as Direct Carcinogens; 2.2 Infectious Agents as Indirect Carcinogens; 2.2.1 Induction of Chromosomal Aberrations; References; 3 Tumors Linked to Infections: Some General Aspects; 3.1 Tumor Types Linked to Infections 327 $a3.2 Global Contributions of Infections to Human Cancers3.3 Host Interactions with Potentially Carcinogenic Infections: The CIF Concept; 3.3.1 The CIF-I Cascade; 3.3.2 The CIF-II Cascade; 3.3.3 The CIF-III Cascade; References; 4 Herpesviruses and Oncogenesis; References; 4.1 Alphaherpesvirinae; 4.1.1 Herpes Simplex Viruses Types 1 and 2; 4.1.2 Varicella-Zoster Virus; References; 4.2 Betaherpesvirinae; 4.2.1 Human Cytomegalovirus; 4.2.2 Human Herpesvirus Type 6; References; 4.3 Gammaherpesvirinae (Lymphocryptoviruses); 4.3.1 Epstein-Barr Virus 327 $a4.3.1.1 Characterization of the Virus, and its Biological Properties4.3.1.2 EBV Gene Products in Latent Infection; 4.3.1.3 Transforming Properties of EBV and Tumor Induction in Animals; 4.3.1.4 Various Stages of Epstein-Barr Viral Latency; 4.3.1.5 EBV in Infectious Mononucleosis; 4.3.1.6 EBV in X-Chromosome-Linked Lymphoproliferative Disease; 4.3.1.7 EBV in Immunoblastic Lymphoma; 4.3.1.8 EBV in Burkitt's Lymphoma; 4.3.1.9 EBV in Nasopharyngeal Carcinoma; 4.3.1.10 EBV in Hodgkin's Disease; 4.3.1.11 EBV in Gastric and Esophageal Carcinomas; 4.3.1.12 EBV in NK/T-Cell Lymphomas 327 $a4.3.1.13 EBV and Other Human CancersReferences; 4.4 Rhadinoviruses; 4.4.1 Human Herpesvirus Type 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus); 4.4.1.1 Historical Background; 4.4.1.2 Epidemiology and Mode of Transmission; 4.4.1.3 Pathogenesis: Other Diseases Associated with HHV-8 Infections; 4.4.1.4 Viral Genes Expressed in Viral Latency; 4.4.1.5 Cellular Genes Regulating Viral Latency; 4.4.1.6 Interaction Between HIV and HHV-8; 4.4.1.7 Viral Homologues to Host Cell Genes and Evasion from the Host's Immune Mechanisms; 4.4.1.8 HHV-8-Related Herpesviruses in Nonhuman Primates 327 $a4.4.2 Marek's Disease of ChickensReferences; 5 Papillomavirus Infections: A Major Cause of Human Cancers; 5.1 Introduction; 5.1.1 Structure of the Viral Particle, Transcriptional Regulation, and Taxonomy; 5.1.2 Transmission and Natural History of Papillomavirus Infections; 5.1.3 Functions of Viral Proteins; 5.1.3.1 E6; 5.1.3.2 E6*; 5.1.3.3 E7; 5.1.3.4 E5; 5.1.3.5 E1; 5.1.3.6 E2; 5.1.3.7 E4; 5.2 The Concept of Cellular Interfering Cascades: Immunological, Intracellular and Paracrine Host Factors Influencing Viral Oncogene Expression or Function; 5.2.1 Immunological Control 327 $a5.2.2 CIF-I: Recognition System and its Disturbance 330 $aWritten by the Nobel Prize Laureate in Physiology or Medicine 2008 In the 1970s, the author of this work and his co-workers initially found Epstein-Barr virus DNA in Burkitt's lymphomas and nasopharyngeal cancer and made the connection between HPV infection and cervical cancer. It was also during this period and subsequently that scientists all over the world discovered tumor-inducing bacteria, viruses, parasites, and protozoa, opening up entirely new prospects for the prevention and treatment of infection-induced cancer by vaccination. Adopting a unifying concept and a consistent s 606 $aViral carcinogenesis 606 $aMicrobial carcinogenesis 615 0$aViral carcinogenesis. 615 0$aMicrobial carcinogenesis. 676 $a616.994071 700 $aZur Hausen$b Harald$05111 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910841169403321 996 $aInfections causing human cancer$94144540 997 $aUNINA