LEADER 03528nam 22004813 450 001 9910841020803321 005 20230629210210.0 010 $a1-119-10407-6 010 $a1-119-10408-4 010 $a1-119-10410-6 035 $a(CKB)4330000000008550 035 $a(MiAaPQ)EBC6939966 035 $a(Au-PeEL)EBL6939966 035 $a(OCoLC)1328133615 035 $a(PPN)266643361 035 $a(EXLCZ)994330000000008550 100 $a20220711d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetic analysis of complex diseases /$fedited by William K. Scott and Marylyn D. Ritchie 205 $a3rd ed. 210 1$aNewark :$cJohn Wiley & Sons, Incorporated,$d2022. 210 4$dİ2022. 215 $a1 online resource (339 pages) 311 $a1-118-12391-3 327 $aDesigning A Study For Identifying Genes In Complex Traits / William K. Scott, Marylyn D. Ritchie, Jonathan L. Haines, and Margaret A. Pericak-Vance -- Basic Concepts In Genetics / Kayla Fourzali, Abigail Deppen, and Elizabeth Heise -- Defining Disease Phenotypes / C. Hung and O. Bodamer -- Determining The Genetic Component of A Disease / Allison Ashley Koch and Evadnie Rampersaud -- Study Design For Genetic Studies / Dana C Crawford and Logan Dumitrescu -- Responsible Conduct of Research In Genetic Studies / Susan Estabrooks Hahn, Adam Buchanan, and Susan H. Blanton -- Linkage Analysis / Susan Blanton -- Data Management / Stephen D. Turner and William S. Bush -- Linkage Disequilibrium and Association Analysis / Eden R. Martin and Ren-Hua Chung -- Genome-Wide Association Studies / Jacob McCauley, Yogasudha Veturi, Shefali Setia Verma, and Marylyn D. Ritchie -- Bioinformatics of Human Genetic Disease Studies / Dale J. Hedges -- Complex Genetic Interactions / Data Mining/ Dimensionality Reduction -- William S. Bush and Stephen D. Turner -- Sample Size, Power, and Data Simulation / Sarah A. Pendergrass, Yi-ju Li, Susan Shao, Marylyn D. Ritchie. 330 0 $aGenetic Analysis of Complex Diseases, Third Edition provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human complex genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human complex genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. These studies promise a greater understanding of the genetic basis of common disorders, improved ability to detect risk factors, and development of new treatment strategies. The new edition of Genetics Analysis of Complex Disease is a unique and much needed resource as more and more clinical researchers are increasingly adopting a genetic perspective to investigate disease etiology, diagnostics, and prognostics. 606 $aGenetics 606 $aGenetic disorders in children 615 0$aGenetics. 615 0$aGenetic disorders in children. 676 $a616.042 701 $aRitchie$b Marylyn D$01075754 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910841020803321 996 $aGenetic analysis of complex diseases$94141628 997 $aUNINA