LEADER 04813nam 2200661Ia 450 001 9910840832703321 005 20211007145841.0 010 $a1-280-94135-9 010 $a9786610941353 010 $a0-470-72379-3 010 $a0-470-72378-5 035 $a(CKB)1000000000356125 035 $a(EBL)309824 035 $a(SSID)ssj0000200678 035 $a(PQKBManifestationID)11183525 035 $a(PQKBTitleCode)TC0000200678 035 $a(PQKBWorkID)10231002 035 $a(PQKB)11192421 035 $a(MiAaPQ)EBC309824 035 $a(OCoLC)181344646 035 $a(PPN)152399275 035 $a(EXLCZ)991000000000356125 100 $a20060906d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMedicines from animal cell culture$b[electronic resource] /$f[edited by] Glyn Stacey, John Davis 210 $aChichester ;$aHoboken, N.J. $cWiley$dc2007 215 $a1 online resource (696 p.) 300 $aDescription based upon print version of record. 311 $a0-470-85094-9 320 $aIncludes bibliographical references and index. 327 $aMedicines from Animal Cell Culture; Contents; Contributors; Preface; List of Abbreviations; 1 The Development of Animal Cell Products: History and Overview 1; FUNDAMENTAL ELEMENTS OF CELL GROWTH MEDIA 15; 2 Water Purity and Regulations; 3 Development and Optimization of Serum-free and Protein-free Media; 4 Understanding Animal Sera: Considerations for Use in the Production of Biological Therapeutics; CELL ENGINEERING FOR RECOMBINANT PRODUCTS; 5 Expression of Recombinant Biomedical Products from Continuous Mammalian Cell Lines; 6 Production of Recombinant Viral Vaccine Antigens 327 $a7 A Brief Overview of the Baculovirus Expression System in Insect and Mammalian Cells8 Stability: Establishing Clones, Genetic Monitoring and Biological Performance; 9 Gene Transfer Vectors for Clinical Applications; TECHNOLOGY AND FACILITIES FOR CELL CULTURE SCALE-UP; 10 Systems for Cell Culture Scale-up; 11 Process Development and Design; 12 Facility Design for Cell Culture Biopharmaceuticals; 13 Monitoring, Control and Automation in Upstream Processing; 14 Services and Associated Equipment for Upstream Processing; 15 System and Process Validation 327 $aPROCESSING AND PRESERVATION OF CELLS AND PRODUCTS16 Cell Harvesting; 17 Protein Concentration; 18 Purifi cation Methods; 19 Virus Safety of Cell-derived Biological Products; 20 Formulation and Freeze Drying for Lyophilized Biological Medicines; 21 Cell Preservation; PROPERTIES OF CELL PRODUCTS; 22 Product Characterization from Gene to Therapeutic Product; 23 Protein Analysis; 24 Glycosylation of Medicinal Products; 25 Immunogenicity of Impurities in Cell-Derived Vaccines; 26 Potency and Safety Assessment of Vaccines and Antitoxins:Use of Cell-based Assays 327 $a27 Product Stability and Accelerated Degradation StudiesCELLS AS PRODUCTS; 28 Cell Culture in Tissue Engineering; 29 The Use of Stem Cells in Cell Therapy; 30 Cells as Vaccines; RISK ASSESSMENT AND REGULATORY ASPECTS; 31 Risk Assessment of Cell Culture Procedures; 32 Standardization of Cell Culture Procedures; 33 Good Laboratory Practice for Cell Culture Processing; 34 Good Manufacturing Practice for Cell Culture Processing; 35 International Regulatory Framework; 36 New Areas: Cell Therapy and Tissue Engineering Products-Technical, Legal and Regulatory Considerations; Index 330 $aMedicines from Animal Cell Culture focuses on the use of animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration and the culture of stem cells. Medicines from Animal Cell Culture:Provides comprehensive descriptions of methods for cell culture and nutrition as well as the technologies for the preservatio 606 $aAnimal cell biotechnology 606 $aPharmaceutical biotechnology 606 $aStem cells$xTransplantation 606 $aRecombinant proteins$xTherapeutic use 615 0$aAnimal cell biotechnology. 615 0$aPharmaceutical biotechnology. 615 0$aStem cells$xTransplantation. 615 0$aRecombinant proteins$xTherapeutic use. 676 $a571.638 676 $a615/.19 701 $aStacey$b G$g(Glyn)$01728891 701 $aDavis$b John$f1952-$0868987 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910840832703321 996 $aMedicines from animal cell culture$94138279 997 $aUNINA