LEADER 04458nam 2200661Ia 450 001 9910840786103321 005 20200805222318.0 010 $a1-282-36879-6 010 $a9786612368790 010 $a0-470-49513-8 010 $a0-470-49512-X 035 $a(CKB)1000000000821977 035 $a(EBL)468740 035 $a(SSID)ssj0000287782 035 $a(PQKBManifestationID)11236192 035 $a(PQKBTitleCode)TC0000287782 035 $a(PQKBWorkID)10371765 035 $a(PQKB)10450562 035 $a(MiAaPQ)EBC468740 035 $a(JP-MeL)3000068187 035 $a(OCoLC)413003421 035 $a(PPN)243341814 035 $a(EXLCZ)991000000000821977 100 $a20090327d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aABC transporters and multidrug resistance$b[electronic resource] /$fedited by Ahce?ne Boumendjel, Jean Boutonnat, Jacques Robert 210 $aHoboken, NJ $cJohn Wiley & Sons$dc2009 215 $a1 online resource (475 p.) 225 1 $aWiley series in drug discovery and development 300 $aDescription based upon print version of record. 311 $a0-470-22734-6 320 $aIncludes bibliographical references and index. 327 $aABC TRANSPORTERS AND MULTIDRUG RESISTANCE; CONTENTS; PREFACE; CONTRIBUTORS; INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE?; PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION; 1 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule?; 2 Multidrug resistance-associated protein (MRP/ABCC proteins); 3 ABCG2: A new challenge in cancer drug resistance 327 $aPART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS4 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia; 5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors; PART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS; 6 ABC transporters and resistance to antibiotics; 7 ABC proteins involved in protozoan parasite resistance 327 $aPART IV MULTIDRUG RESISTANCE (MDR) MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS: DESIGN OF INHIBITORS AND MECHANISM OF ACTION8 Reversal agents for P-glycoprotein-mediated multidrug resistance; 9 Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs); 10 Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance; 11 Strategies to overcome drug resistance in acute and chronic leukemias; 12 Multidrug resistance reversal in solid tumors 327 $aPART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE: THE ROLE OF THE TRANSPORTERS AT THE MAIN PROTECTION BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE BIOAVAILABILITY OF MANY TYPES OF DRUGS AND MEDICATIONS13 ABC superfamily transporters at the human blood-brain barrier; 14 The role of ABC transporters at the intestinal barrier; 15 Genetic polymorphisms in ABC transporters; PERSPECTIVES; INDEX 330 $aA comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential r 410 0$aWiley series in drug discovery and development. 606 $aATP-binding cassette transporters 606 $aDrug resistance in cancer cells 615 0$aATP-binding cassette transporters. 615 0$aDrug resistance in cancer cells. 676 $a572/.696 676 $a615.1 701 $aBoumendjel$b Ahce?ne$01727515 701 $aBoutonnat$b Jean$01727516 701 $aRobert$b Jacques$cM.D.$0425177 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910840786103321 996 $aABC transporters and multidrug resistance$94134792 997 $aUNINA