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100   $a20060125d2006      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aChirality in drug research$b[electronic resource] /$fedited by Eric Francotte and Wolfgang Lindner
210   $aWeinheim $cWiley-VCH$dc2006
215   $a1 online resource (373 p.)
225 1 $aMethods and principles in medicinal chemistry ;$vv. 33
300   $aDescription based upon print version of record.
311   $a3-527-31076-2 
320   $aIncludes bibliographical references and index.
327   $aChiral drugs from a historical point of view / Joseph Gal -- Stereoselective synthesis of drugs : an industrial perspective / Hans-Ju?rgen Federsel -- Aspects of chirality in natural products drug discovery / Philipp Krastel, Frank Petersen, Silvio Roggo, Esther Schmitt, Ansgar Schuffenhauer -- Biotransformation methods for preparing chiral drugs and drug intermediates / Michael Mu?ller, Marcel Wubbolts -- Resolution of chiral drugs and drug intermediates by crystallisation / Kazuhiko Saigo and Kenichi Sakai -- Isolation and production of optically pure drugs by enantioselective chromatography / Eric Francotte -- Stereoselective chromatographic methods for drug analysis / Norbert M. Maier, Wolfgang Lindner -- Capillary electrophoresis coupled to mass spectrometry for chiral drugs analysis / Serge Rudaz, Jean-Luc Veuthey -- Powerful chiral molecular tools for preparation of enantiopure alcohols and simultaneous determination of their absolute configurations by X-ray crystallography and/or  p1 sH NMR anisotropy methods / Nobuyuki Harada -- Keywords in chirality modeling : molecular modeling of chirality : software and literature research on chirality in modeling, chirality in docking, chiral ligand-receptor interaction and symmetry / Gerd Folkers, Mine Yarim, Pavel Pospisil.
330   $aDivided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative
410  0$aMethods and principles in medicinal chemistry ;$vv. 33.
606   $aChiral drugs
606   $aDrugs$xResearch
606   $aDrug development
606   $aMe?dicaments$xRecherche
606   $aMe?dicaments$xDe?veloppement
610  0$alegemidler$aforskning$alegemiddelutvikling$alegemiddelanalyse$afarmasøytisk kjemi$amedikamenter$amedisiner$alegemiddelkjemi$asyntese
615  0$aChiral drugs.
615  0$aDrugs$xResearch.
615  0$aDrug development.
615  6$aMe?dicaments$xRecherche.
615  6$aMe?dicaments$xDe?veloppement.
676   $a615.19
701   $aFrancotte$b Eric$01729197
701   $aLindner$b W$g(Wolfgang)$01729198
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910840775703321
996   $aChirality in drug research$94138901
997   $aUNINA