LEADER 03575nam 2200637 a 450 001 9910840773903321 005 20230331005418.0 010 $a1-282-34763-2 010 $a9786612347634 010 $a0-470-51388-8 010 $a0-470-51389-6 035 $a(CKB)1000000000377202 035 $a(EBL)470466 035 $a(OCoLC)609849373 035 $a(SSID)ssj0000303505 035 $a(PQKBManifestationID)11266370 035 $a(PQKBTitleCode)TC0000303505 035 $a(PQKBWorkID)10275303 035 $a(PQKB)10425944 035 $a(MiAaPQ)EBC470466 035 $a(EXLCZ)991000000000377202 100 $a19890920d1990 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular control of haemopoiesis$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1990 215 $a1 online resource (244 p.) 225 1 $aCiba Foundation symposium ;$v148 300 $aPapers from a symposium held at the CIBA Foundation, London, May 2-4, 1989. 300 $aEditors, Greg Bock (organizer) and Joan Marsh. 300 $a"A Wiley-Interscience publication." 311 $a0-471-92561-6 320 $aIncludes bibliographical references and indexes. 327 $aMOLECULAR CONTROL OF HAEMOPOIESIS; Contents; Introduction; The proteins that control haemopoiesis and leukemia; Protein factors that regulate the growth and differentiation of mouse myeloid leukemia cells; Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation; Responses of neutrophils to myeloid growth factors; Stromal cells in haemopoiesis; Signal-response coupling mediated by the transduced colony-stimulating factor-I receptor and its oncogenic fms variants in naive cells 327 $aCharacteristics of soluble and membrane-bound forms of haemopoietic growth factor receptors: relationships to biological function Haemopoietic growth factor regulation of protein kinases and genes associated with cell proliferation; Contributions of autocrine and non-autocrine mechanisms to tumorigenicity in a murine model for leukemia; The mouse W/c-kit locus; Retroviral infection and haemopoiesis; The use of recombinant human erythropoietin in humans; Growth factor-assisted chemotherapy-the Manchester experience; General discussion; Summary; Index of contributors; Subject index 330 $aThe many different kinds of blood cells found in the human body are derived from multi-potential stem cells, which are induced to differentiate into one or another cell type by the action of regulatory proteins or growth factors. This volume looks at the way that binding of these proteins to specific receptors causes changes in gene expression in the nucleus and the activity of certain enzymes in the cytoplasm, committing the cell to a particular developmental pathway. Also discussed are recently established clinical applications and clinical trials of new techniques. 410 0$aCiba Foundation symposium ;$v148. 606 $aHematopoiesis$vCongresses 606 $aGrowth factors$xPhysiological effect$vCongresses 615 0$aHematopoiesis 615 0$aGrowth factors$xPhysiological effect 676 $a599 676 $a599.011 676 $a612.11 701 $aBock$b Gregory$0322650 701 $aMarsh$b Joan$091633 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910840773903321 996 $aMolecular control of haemopoiesis$94138895 997 $aUNINA