LEADER 05315nam 2200697Ia 450 001 9910840685303321 005 20230607215337.0 010 $a9786611239299 010 $a1-281-23929-1 010 $a1-280-55842-3 010 $a9786610558421 010 $a3-527-61272-6 010 $a3-527-60072-8 035 $a(CKB)1000000000019286 035 $a(EBL)482370 035 $a(SSID)ssj0000303193 035 $a(PQKBManifestationID)11249155 035 $a(PQKBTitleCode)TC0000303193 035 $a(PQKBWorkID)10275614 035 $a(PQKB)11324818 035 $a(MiAaPQ)EBC482370 035 $a(MiAaPQ)EBC4957940 035 $a(Au-PeEL)EBL4957940 035 $a(CaONFJC)MIL55842 035 $a(OCoLC)52807738 035 $a(EXLCZ)991000000000019286 100 $a20010410d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMicrobial transport systems$b[electronic resource] /$fGu?nther Winkelmann, ed 210 $aWeinheim ;$aNew York $cWiley-VCH$dc2001 215 $a1 online resource (534 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30304-9 320 $aIncludes bibliographical references and index. 327 $aMicrobial Transport Systems; Preface; Contents; List of Authors; Color Plates; 1 Families of Transporters: A Phylogenetic Overview; 1.1 Introduction; 1.2 The TC System; 1.3 The Value of Phylogenetic Classification; 1.4 Phylogeny as Applied to Transporters; 1.5 The Basis for Classification in the TC System; 1.6 Classes of Transporters; 1.7 Class 1: Channels/Pores; 1.8 Class 2: Electrochemical Potential-driven Porters; 1.9 Class 3: Primary Active Transporters; 1.10 Class 4: Group Translocators; 1.11 Class 8: Accessory Factors Involved in Transport 327 $a1.12 Class 9: Incompletely Characterized Transport Proteins1.13 Transporters with Dual Modes of Energy Coupling; 1.14 Transporters Exhibiting More than One Mode of Transport; 1.15 Conclusions and Perspectives; References; 2 Energy-transducing Ion Pumps in Bacteria : Structure and Function of ATP Synthases; 2.1 Introduction; 2.2 Overview; 2.3 Structure, Configuration, and Interaction of F(1) Subunits; 2.4 Catalysis: Structural and Mechanistic Implications within the F(1) Complex; 2.5 The F(1)/F(O) Interface: Contact Sites for Energy Transmission 327 $a2.6 Structure, Configuration, and Interaction of F(O) Subunits2.7 Catalysis: Coupling Ion Translocation to ATP Synthesis; References; 3 Sodium/Substrate Transport; 3.1 Introduction; 3.2 Occurrence and Role of Na(+) /Substrate Transport Systems; 3.2.1 General Considerations; 3.2.2 Elevated Temperatures; 3.2.3 Na(+) -rich Environments; 3.2.4 High pH; 3.2.5 Citrate Fermentation; 3.2.6 Na(+) /Substrate Transport in Escherichia coli; 3.2.7 Osmotic Stress; 3.3 Functional Properties of Na(+) /Substrate Transport Systems; 3.3.1 General Considerations; 3.3.2 MelB; 3.3.3 PutP; 3.3.4 CitS 327 $a3.4 Transporter Structure3.4.1 General Features; 3.4.2 MelB; 3.4.3 PutP and Other Members of the SSF; 3.4.4 CitS; 3.5 Structure -Function Relationships; 3.5.1 MelB; 3.5.1.1 Site of Ion Binding; 3.5.1.2 Sugar Binding and Functional Dynamics of MelB; 3.5.2 PutP; 3.5.2.1 Site of Na(+) Binding; 3.5.2.2 Regions Important for Proline Binding; 3.5.2.3 Functional Dynamics of PutP; 3.5.3 CitS; 3.6 Concluding Remarks and Perspective; References; 4 Prokaryotic Binding Protein-dependent ABC Transporters; 4.1 A Brief History of ABC Systems; 4.2 What is an ABC System? 327 $a4.3 The Composition of the Prokaryotic ABC Transporters4.4 Associated Proteins and Signal Transduction Pathways; 4.5 The Components; 4.5.1 The Binding Proteins; 4.5.1.1 Substrate Recognition Sites are High-affinity Soluble Binding Proteins; 4.5.1.2 The Binding Test; 4.5.1.3 Special Examples; 4.5.1.4 Binding Proteins Undergo Conformational Changes upon Binding Substrate; 4.5.1.5 The Crystal Structure; 4.5.2 The Integral Transmembrane Domains (TMDs); 4.5.2.1 Organization; 4.5.2.2 Composition and Structure; 4.5.2.3 The Interaction of the TMDs with the Binding Protein; 4.5.2.4 The Sequence 327 $a4.5.3 The ABC Subunit 330 $aTransport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds. 606 $aBiological transport 606 $aMicrobial growth 606 $aMicroorganisms$xDevelopment 615 0$aBiological transport. 615 0$aMicrobial growth. 615 0$aMicroorganisms$xDevelopment. 676 $a571.64 676 $a571.82 701 $aWinkelmann$b Gu?nther$091995 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910840685303321 996 $aMicrobial transport systems$94141680 997 $aUNINA