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024 7 $a10.1007/978-3-031-41943-0
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035   $a(DE-He213)978-3-031-41943-0
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100   $a20240219d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPluripotent Stem Cell Therapy for Diabetes$b[electronic resource] /$fedited by Lorenzo Piemonti, Jon Odorico, Timothy J . Kieffer, Valeria Sordi, Eelco de Koning
205   $a1st ed. 2023.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023.
215   $a1 online resource (597 pages)
311   $a3-031-41942-1 
327   $aMimicking pancreas development with human pluripotent stem cells -- Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming -- The evolution of methods for in vitro differentiation of stem cell derived islets -- Signaling pathways that govern the formation, expansion and maturation of pancreatic progenitors -- Building islets from the ground up using stem cells -- Pancreatic progenitor proliferation -- Selecting biocompatible biomaterials for stem cell derived islet transplantation -- Scaffolds for encapsulation of stem-cell-derived ? cells -- 3d printing of new islets -- Biological scaffolds and hydrogels in islet organoids -- 3-D organoids of mesenchymal stromal and pancreatic islet cells -- Bioengineered insulin producing endocrine tissues -- Bioactive materials for cell encapsulation -- Strategies to boost islet graft oxygenation -- Vascularizing device strategies -- Immunogenicity of stem cell derived islets -- Immune evasive stem cell islets -- Encapsulation of stem cell-derived islets: recent progress -- Islet immunoengineering -- Stem cell genome editing tools -- Selection of SC-derived pancreatic progenitors and ? cell -- Considerations pertaining to implant sites for cell-based insulin replacement -- Safety switches in pluripotent stem cells -- Safety: teratoma risk -- Stem cell derived islets transplantation in non-human primates -- Social / Legal / Ethical issues pertaining to use of pluripotent stem cells -- Cost-effectiveness considerations for stem cell derived islet replacement therapy -- Lessons from clinical trials of islet cell replacement -- Scale up and Biomanufacturing of Stem Cell- derived Islets -- Minimal SC-? cell properties for transplantation in diabetic patients -- Autologous stem cell islets for patients with chronic pancreatitis and diabetes -- Clinical Trials -- Modeling monogenic diabetes with stem cells -- Stem and progenitor cells in pancreas development, regeneration and drug screening. .
330   $aThis is a unique book containing comprehensive coverage of pluripotent stem cell therapies for the treatment of diabetes. The greatest enthusiasm for treatment lies in the possibility of using stem cells to overcome the limits of islet transplantation. Organized into six parts, this book covers the development and differentiation of beta cells, bioengineering, immunoescape, preclinical model and translational approaches, beta cell replacement, and disease modeling. This is an ideal book for scientists, researchers, and clinicians working in the area of stem cell technology in the treatment of diabetes.
606   $aStem cells
606   $aRegenerative medicine
606   $aBiomaterials
606   $aCells
606   $aImmunotherapy
606   $aDevelopmental biology
606   $aStem Cell Biology
606   $aRegenerative Medicine and Tissue Engineering
606   $aBiomaterials-Cells
606   $aImmunotherapy
606   $aDevelopmental Biology and Stem Cells
615  0$aStem cells.
615  0$aRegenerative medicine.
615  0$aBiomaterials.
615  0$aCells.
615  0$aImmunotherapy.
615  0$aDevelopmental biology.
615 14$aStem Cell Biology.
615 24$aRegenerative Medicine and Tissue Engineering.
615 24$aBiomaterials-Cells.
615 24$aImmunotherapy.
615 24$aDevelopmental Biology and Stem Cells.
676   $a571.6
676   $a616.02774
700   $aPiemonti$b Lorenzo$0453902
701   $aOdorico$b Jon$01726266
701   $aKieffer$b Timothy J.$01726267
701   $aSordi$b Valeria$01726268
701   $ade Koning$b Eelco$01726269
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910838275603321
996   $aPluripotent Stem Cell Therapy for Diabetes$94131988
997   $aUNINA