LEADER 01052nam0-22003131i-450- 001 990000697330403321 005 20040611112454.0 035 $a000069733 035 $aFED01000069733 035 $a(Aleph)000069733FED01 035 $a000069733 100 $a20020821d1966----km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aSicilia$fa cura dell'Unione delle Camere di Commercio della Regione siciliana$gcoord. Stefano Somogyi 210 $aMilano$cGiuffrè$d1966 215 $aXV, 269 p.$d24 cm 225 1 $aMonografie regionali per la programmazione economica 300 $aIn testa al front.: Unione Italiana delle Camere di Commercio Industria e Agricoltura 702 1$aSomogyi,$bStefano 712 02$aUnione regionale delle camere di commercio industria artigianato e agricoltura della Sicilia 712 02$aUnioncamere 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000697330403321 952 $a01 EC 53$b1393$fDINST 959 $aDINST 996 $aSicilia$9160907 997 $aUNINA LEADER 03850nam 2200433 450 001 9910831194203321 005 20230629215907.0 010 $a1-119-65203-0 010 $a1-119-65204-9 010 $a1-119-65205-7 035 $a(MiAaPQ)EBC6889695 035 $a(Au-PeEL)EBL6889695 035 $a(CKB)21251114000041 035 $a(EXLCZ)9921251114000041 100 $a20220926d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAbnormal chromosomes $ethe past, present, and future of cancer cytogenetics /$fSverre Heim, Felix Mitelman 210 1$aHoboken, New Jersey :$cWiley-Blackwell,$d[2022] 210 4$d©2022 215 $a1 online resource (211 pages) 311 08$aPrint version: Heim, Sverre Abnormal Chromosomes Newark : John Wiley & Sons, Incorporated,c2022 9781119651987 320 $aIncludes bibliographical references and index. 330 $a"Explore the past, present, and future of cancer cytogenetics In Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics -- the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics. The book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders. From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process? How was information of this nature put to good use in the clinical management of cancer patients? Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics offers readers: A thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed Comprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer. A detailed chronological resume of cancer cytogenetic discoveries during the century. In-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populations. A discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation. The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients"--$cProvided by publisher. 606 $aChromosome abnormalities 615 0$aChromosome abnormalities. 676 $a616.994042 700 $aHeim$b Sverre$01608037 702 $aMitelman$b Felix 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831194203321 996 $aAbnormal chromosomes$93934577 997 $aUNINA