LEADER 03694nam 2200481 450 001 9910831183103321 005 20230220161943.0 010 $a1-68367-379-4 010 $a1-68367-361-1 035 $a(MiAaPQ)EBC7097764 035 $a(Au-PeEL)EBL7097764 035 $a(CKB)24866178400041 035 $a(EXLCZ)9924866178400041 100 $a20230220d2022 uy 0 101 0 $aeng 135 $aurcz#---auuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCrispr $ebiology and applications /$fedited by Erik J. Sontheimer, Luciano A. Marraffini, and Rodolphe Barrangou 210 1$aWashington, District of Columbia :$cAmerican Society for Microbiology,$d[2022] 210 4$dİ2022 215 $a1 online resource (502 pages) 225 1 $aASM Bks. 300 $a"Copublication by the American Society for Microbiology and John Wiley & Sons, Inc."-- copyright page. 311 08$aPrint version: Sontheimer, Erik J. Crispr Newark : ASM Press,c2022 9781683670377 320 $aIncludes bibliographical references and index. 327 $aCRISPR-Cas Systems : Core Features and Common Mechanisms / Rodolphe Barrangou, Luciano A. Marraffini, and Erik Sontheimer -- Evolutionary Classification of CRISPR-Cas Systems / Kira S. Makarova, Yuri I. Wolf, Eugene V. Koonin -- Molecular Mechanisms of Type I CRISPR-Cas Systems / John van der Oost -- Molecular Mechanisms of Type II CRISPR-Cas Systems / Tautvydas Karvelis and Virginijus S?iks?nys -- Mechanism of Type III CRISPR-Cas Immunity / Luciano A. Marraffini -- Type V CRISPR-Cas Systems / Morgan Quinn Beckett, Anita Ramachandran, and Scott Bailey -- CRISPR-Cas13 : Biology, Mechanism, and Applications of RNA-Guided, RNA-Targeting CRISPR Systems / Omar O. Abudayyeh -- CRISPR-Cas, Horizontal Gene Transfer, and the Flexible (Pan) Genome / Uri Gophna -- Evasion Tactics Manifested by Bacteriophages against Bacterial Immunity / Joseph Bondy-Denomy -- Regulation of CRISPR-Cas Expression and Function / Leah M. Smith, Aroa Rey Campa, and Peter C. Fineran -- Genome Editing with CRISPR-Cas Systems / Peter Lotfy and Patrick D. Hsu -- Genetic and Epigenetic Modulation of Gene Expression by CRISPR-dCas Systems / Jasprina N. Noordermeer, Crystal Chen, and Lei S. Qi -- CRISPR Screens / Jonathan D. D'Gama, Joseph S. Park, and Matthew K. Waldor -- CRISPR-Based Antimicrobials / Justen Russell and David Bikard -- Exploiting CRISPR-Cas Systems to Provide Phage Resistance in Industrial Bacteria / Rodolphe Barrangou and Avery Roberts -- Recording Biological Information with CRISPR-Cas Systems / Mariia Y. Cherepkova, Tanmay Tanna, and Randall J. Platt 330 $a"Since their discovery and subsequent development into laboratory tools, CRISPR Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR Biology and Applications explores the subject matter needed to delve into this fascinating area. This comprehensive text presents the diversity of CRISPR Cas systems, the underlying biology of these systems, and CRISPR based technologies and applications"--$cProvided by publisher. 410 0$aASM bookshelf series. 606 $aBiotechnology 615 0$aBiotechnology. 676 $a343.430786606 702 $aSontheimer$b Erik J. 702 $aMarraffini$b Luciano A. 702 $aBarrangou$b Rodolphe 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831183103321 996 $aCRISPR$92138587 997 $aUNINA