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100   $a20070626d2008      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGrowth factors and psychiatric disorders$b[electronic resource]
210   $aChichester, UK ;$aHoboken, NJ $cJohn Wiley & Sons$d2008
215   $a1 online resource (260 p.)
225 1 $aNovartis Foundation symposium ;$v289
300   $a"Editors: Derek J. Chadwick (organizer) and Jamie Goode"--P. v.
311   $a0-470-51604-6 
320   $aIncludes bibliographical references and indexes.
327   $aGROWTH FACTORS AND PSYCHIATRIC DISORDERS; Contents; Chair's introduction; Phenomenology, aetiology and treatment of schizophrenia; DISCUSSION; Genetic variants in major depression; DISCUSSION; Neurotrophins in depression and antidepressant effects; DISCUSSION; Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism; DISCUSSION; Mechanisms of neuregulin action; DISCUSSION; General discussion I; The fibroblast growth factor family and mood disorders; DISCUSSION; Trajectories of anatomic brain development as a phenotype; DISCUSSION
327   $aCell biology of BDNF and its relevance to schizophreniaDISCUSSION; Functions and mechanisms of BDNF mRNA trafficking; DISCUSSION; Hippocampal neurogenesis and depression; DISCUSSION; Neuregulins and neuronal plasticity: possible relevance in schizophrenia; DISCUSSION; Impact of genetic variant BDNF (Val66Met) on brain structure and function; DISCUSSION; General discussion II; Growth and schizophrenia: aetiology, epidemiology and epigenetics; DISCUSSION; What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?; DISCUSSION
327   $aNeurotrophins and cytokines in neuronal plasticityDISCUSSION; Closing remarks; Contributor Index; Subject Index
330   $aThe recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development
410  0$aNovartis Foundation symposium ;$v289.
606   $aGrowth factors
606   $aMental illness$xGenetic aspects
615  0$aGrowth factors.
615  0$aMental illness$xGenetic aspects.
676   $a616.89042
701   $aChadwick$b Derek$091632
701   $aGoode$b Jamie$0283336
712 02$aNovartis Foundation.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910831177003321
996   $aGrowth factors and psychiatric disorders$93926801
997   $aUNINA