LEADER 04612nam 2200469 450 001 9910831067303321 005 20240118063619.0 010 $a3-527-80289-4 010 $a3-527-80290-8 010 $a3-527-80288-6 035 $a(CKB)4330000000010779 035 $a(MiAaPQ)EBC5407754 035 $a(EXLCZ)994330000000010779 100 $a20180621d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEctoparasites $edrug discovery against moving targets /$fedited by Charles Q. Meng and Ann E. Sluder 210 1$aWeinheim, Germany :$cWiley-VCH,$d[2018] 210 4$d©2018 215 $a1 online resource (379 pages) 225 1 $aDrug Discovery in Infections Diseases ;$vVolume 8 311 $a3-527-34168-4 327 $aStrategies & Resistance. Comparison of Anti-ectoparasite and Anti-endoparasite Therapies and Control Strategies / Debra J Woods, Tom L McTier, Andrew A DeRosa -- Vaccination Against Ticks / Theo PM Schetters -- Blocking Transmission of Vector-borne Diseases / Sandra Schorderet-Weber, Sandra Noack, Paul M Selzer, Ronald Kaminsky -- The Threat and Reality of Drug Resistance in the Cattle Tick Rhipicephalus (Boophilus) microplus / Heinz Sager, Le?onore Lovis, Christian Epe, Ronald Kaminsky -- Monitoring Drug Sensitivity in Cattle Ticks / Leonore Lovis, Christian Epe, Ronald Kaminsky, Heinz Sager -- New Developments in the Control of Human Lice / John M Clark -- Screens & Models. Molecular Targets to Impair Blood Meal Processing in Ticks / Petr Kopa?c?ek, Jan Perner, Daniel Sojka, Radek S?i?ma, Ondr?ej Hajdus?ek -- Whole-organism Screens for Ectoparasites / Jeffrey N Clark, Cedric J Pearce -- In vitro Feeding Methods for Hematophagous Arthropods and Their Application in Drug Discovery / Ard M Nijhof, Katharine R Tyson -- Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development / Sandra Schorderet-Weber, Ronald Kaminsky -- Testing in Target Hosts for Ectoparasiticide Discovery and Development / Jeffrey N Clark -- Isoxazolines. Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites / Tina Weber, Paul M Selzer -- The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs / Ming Xu, Jeffrey K Long, George P Lahm, Wesley L Shoop, Daniel Cordova, Ty Wagerle, Ben K Smith, Thomas F Pahutski, Rafael Shapiro, Michael Mahaffey, Eric J Hartline, Brandon R Gould, Molly E Waddell, Richard G McDowell, John B Kinney, Gail S Jones, Robert F Dietrich, Mark E Schroeder, Daniel F Rhoades, Eric A Benner, Pat N Confalone -- Development of Afoxolaner as a New Ectoparasiticide for Dogs / Laura Letendre, Diane Larsen, Mark Soll -- Discovery, Development, and Commercialization of Sarolaner (Simparicaź), A Novel Oral Isoxazoline Ectoparasiticide for Dogs / Debra J Woods, Tom L McTier -- Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty-first Century / Alan Long. 330 $aThis first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry. 410 0$aDrug discovery in infectious diseases ;$vVolume 8. 606 $aAntiparasitic agents 606 $aDrug development 615 0$aAntiparasitic agents. 615 0$aDrug development. 676 $a616.96061 702 $aMeng$b Charles Q. 702 $aSluder$b Ann E. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831067303321 996 $aEctoparasites$9404822 997 $aUNINA