LEADER 03635nam 2200649 a 450 001 9910831059003321 005 20230421044555.0 010 $a1-282-34785-3 010 $a9786612347856 010 $a0-470-51445-0 010 $a0-470-51446-9 035 $a(CKB)1000000000377211 035 $a(EBL)470269 035 $a(SSID)ssj0000298005 035 $a(PQKBManifestationID)11226357 035 $a(PQKBTitleCode)TC0000298005 035 $a(PQKBWorkID)10334743 035 $a(PQKB)10386786 035 $a(MiAaPQ)EBC470269 035 $a(OCoLC)181175095 035 $a(EXLCZ)991000000000377211 100 $a19930316d1993 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe GTPase superfamily$b[electronic resource] /$f[editors, Joan Marsh (organizer) and Jamie Goode] 210 $aChichester ;$aNew York $cWiley$d1993 215 $a1 online resource (302 p.) 225 1 $aCiba Foundation symposium ;$v176 300 $a"Symposium on the GTPase superfamily, held at the Ciba Foundation, London, 17-19 November 1992"--P. [v]. 300 $a"A Wiley-Interscience publication." 311 $a0-471-93914-5 320 $aIncludes bibliographical references and indexes. 327 $aTHE GTPase SUPERFAMILY; Contents; Introduction; Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21; Elongation factors in protein synthesis; RAS function and protein kinase cascades; Cell transformation by ras and regulation of its protein product; Identification of ras targets using a genetic approach; G proteins in signal transduction: the regulation of phospholipase C; The G protein cascade of visual transduction: kinetics and regulation; General discussion I Voltage-dependent Ca2+ channels as GAPS; Regulators of small GTPases 327 $aA GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membraneA cell-physiological description of GE, a GTP-binding protein that mediates exocytosis; Dynamin, a GTPase involved in the initial stages of endocytosis; The VPS1 protein is a dynamin-like GTPase required for sorting proteins to the yeast vacuole; General discussion II : Ras-mediated signalling pathway during vulval development in Caenorhabditis elegans; The cycle of SEC4 function in vesicular transport; Mx proteins: GTPases involved in the interferon-induced antiviral state 327 $aShould the tubulins be members of the GTPase superfamily?Final general discussion; Summing-up; Index of contributors; Subject index 330 $aUsing a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working on all aspects of GTPase activity. Covers all known members of the important superfamily of enzymes--the GTPases. Considers numerous key cellular functions and how they are regulated by GTPases. Also describes various regulatory proteins that modulate GTPase activity. 410 0$aCiba Foundation symposium ;$v176. 606 $aG proteins$vCongresses 606 $aGuanosine triphosphatase$vCongresses 606 $aGuanosine triphosphatase genes$vCongresses 615 0$aG proteins 615 0$aGuanosine triphosphatase 615 0$aGuanosine triphosphatase genes 676 $a574.19 676 $a574.19245 701 $aMarsh$b Joan$091633 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831059003321 996 $aThe GTPase superfamily$93928235 997 $aUNINA