LEADER 03942nam 22006614a 450 001 9910831050903321 005 20230617024658.0 010 $a1-280-27213-9 010 $a9786610272136 010 $a0-470-66781-8 010 $a0-470-86803-1 010 $a0-470-86806-6 035 $a(CKB)111087027097518 035 $a(EBL)164855 035 $a(SSID)ssj0000137989 035 $a(PQKBManifestationID)11146786 035 $a(PQKBTitleCode)TC0000137989 035 $a(PQKBWorkID)10096361 035 $a(PQKB)10183134 035 $a(MiAaPQ)EBC164855 035 $a(OCoLC)66418400 035 $a(EXLCZ)99111087027097518 100 $a20030414d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDevelopment of the cardiac conduction system$b[electronic resource] 210 $aChichester, UK ;$aHoboken, NJ $cJ. Wiley$d2003 215 $a1 online resource (301 p.) 225 1 $aNovartis Foundation symposium ;$v250 300 $a"Symposium on Development of the Cardiac Conduction System, held at the Novartis Foundation, London, May 21-23, 2002"--P. v. 300 $aIncludes bibliographical references and index. 300 $a"Editors, Derek J. Chadwick (organizer) and Jamie Goode"--Contents p. 311 $a0-470-85035-3 320 $aIncludes bibliographical references and index. 327 $aDEVELOPMENT OF THE CARDIAC CONDUCTION SYSTEM; Contents; Participants; Chair's introduction; The morphology of the cardiac conduction system; Discussion; Development of the cardiac conduction system: a matter of chamber development; Discussion; Mouse models for cardiac conduction system development; Discussion; Developmental transitions in cardiac conduction; Discussion; Gap junctional connexins in developing mouse cardiac conduction system; Discussion; His-Purkinje lineages and development; Discussion; The role of neural crest and epicardium-derived cells in conduction system formation 327 $aDiscussionInduction and patterning of the Purkinje fibre network; Discussion; The oldest, toughest cells in the heart; Discussion; Transcriptional regulation in the mouse atrioventricular conduction system; Discussion; Patterning of the mouse conduction system; Discussion; Clinical pathology of the cardiac conduction system; Discussion; Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans; Discussion; The genetic origin of atrioventricular conduction disturbance in humans; Discussion 327 $aDefects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and diseaseDiscussion; Final general discussion; Index of contributors; Subject index 330 $aThe pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts w 410 0$aNovartis Foundation symposium ;$v250. 606 $aHeart conduction system$vCongresses 606 $aHeart$xGrowth$vCongresses 615 0$aHeart conduction system 615 0$aHeart$xGrowth 676 $a612.1/71 676 $a612.17 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831050903321 996 $aDevelopment of the cardiac conduction system$94028020 997 $aUNINA