LEADER 05065nam 2200649Ia 450 001 9910831026903321 005 20170815112953.0 010 $a1-280-73873-1 010 $a9786610738731 010 $a0-470-02003-2 010 $a0-470-02002-4 035 $a(CKB)1000000000357249 035 $a(EBL)284437 035 $a(SSID)ssj0000111867 035 $a(PQKBManifestationID)11124920 035 $a(PQKBTitleCode)TC0000111867 035 $a(PQKBWorkID)10080562 035 $a(PQKB)10971699 035 $a(MiAaPQ)EBC284437 035 $a(OCoLC)180257423 035 $a(EXLCZ)991000000000357249 100 $a20060403d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBioinformatics$b[electronic resource] $egenomics and post-genomics /$fFre?de?ric Dardel and Franc?ois Ke?pe?s ; translated by Noah Hardy 210 $aChichester, England ;$aHoboken, NJ $cJohn Wiley & Sons$dc2006 215 $a1 online resource (253 p.) 300 $a"This work has been published with the help of the French Ministe?re de la Culture - Centre national du livre." 311 $a0-470-02001-6 320 $aIncludes bibliographical references and index. 327 $aCover; Contents; Preface to the French edition; Preface to the English edition; 1: Genome sequencing; 1.1 Automatic sequencing; 1.2 Sequencing strategies; 1.3 Fragmentation strategies; 1.4 Sequence assembly; 1.5 Filling gaps; 1.6 Obstacles to reconstruction; 1.7 Utilizing a complementary 'large'1 clone library; 1.8 The first large-scale sequencing project: The Haemophilus influenzae genome; 1.9 cDNA and EST; 2: Sequence comparisons; 2.1 Introduction: Comparison as a sequence prediction method; 2.2 A sample molecule: the human androsterone receptor 327 $a2.3 Sequence homologies - functional homologies2.4 Comparison matrices; 2.5 The problem of insertions and deletions; 2.6 Optimal alignment: the dynamic programming method; 2.7 Fast heuristic methods; 2.8 Sensitivity, specificity, and confidence level; 2.9 Multiple alignments; 3: Comparative genomics; 3.1 General properties of genomes; 3.2 Genome comparisons; 3.3 Gene evolution and phylogeny: applications to annotation; 4: Genetic information and biological sequences; 4.1 Introduction: Coding levels; 4.2 Genes and the genetic code; 4.3 Expression signals; 4.4 Specific sites 327 $a4.5 Sites located on DNA4.6 Sites present on RNA; 4.7 Pattern detection methods; 5: Statistics and sequences; 5.1 Introduction; 5.2 Nucleotide base and amino acid distribution; 5.3 The biological basis of codon bias; 5.4 Using statistical bias for prediction; 5.5 Modeling DNA sequences; 5.6 Complex models; 5.7 Sequencing errors and hidden Markov models; 5.8 Hidden Markov processes: a general sequence analysis tool; 5.9 The search for genes - a difficult art; 6: Structure prediction; 6.1 The structure of RNA; 6.2 Properties of the RNA molecule; 6.3 Secondary RNA structures 327 $a6.4 Thermodynamic stability of RNA structures6.5 Finding the most stable structure; 6.6 Validation of predicted secondary structures; 6.7 Using chemical and enzymatic probing to analyze folding; 6.8 Long-distance interactions and three-dimensional structure prediction; 6.9 Protein structure; 6.10 Secondary structure prediction; 6.11 Three-dimensional modeling based on homologous protein structure; 6.12 Predicting folding; 7: Transcriptome and proteome: macromolecular networks; 7.1 Introduction; 7.2 Post-genomic methods; 7.3 Macromolecular networks; 7.4 Topology of macromolecular networks 327 $a7.5 Modularity and dynamics of macromolecular networks7.6 Inference of regulatory networks; 8: Simulation of biological processes in the genome context; 8.1 Types of simulations; 8.2 Prediction and explanation; 8.3 Simulation of molecular networks; 8.4 Generic post-genomic simulators; Index 330 $aThis book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected E?cole Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors. After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using informati 606 $aBioinformatics 606 $aGenomics 615 0$aBioinformatics. 615 0$aGenomics. 676 $a570.285 676 $a572.80285 686 $aBIO 110f$2stub 686 $aBIO 180f$2stub 686 $aWC 7700$2rvk 700 $aDardel$b Fre?de?ric$01650891 701 $aKe?pe?s$b Franc?ois$0431234 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910831026903321 996 $aBioinformatics$94000497 997 $aUNINA