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024 7 $a10.1007/978-981-99-9400-7
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035   $a(DE-He213)978-981-99-9400-7
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100   $a20240203d2024      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMetal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases$b[electronic resource] /$fby Keita Mori
205   $a1st ed. 2024.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024.
215   $a1 online resource (137 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
311 08$a9789819993994 
327   $a1. General introduction -- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases -- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides -- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases -- 5. Conclusion and perspectives.
330   $aIn this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
606   $aBiomaterials
606   $aNucleic acids
606   $aCoordination compounds
606   $aNanotechnology
606   $aSelf-assembly (Chemistry)
606   $aNanotechnology
606   $aBiocompatible Materials
606   $aNucleic Acids
606   $aLayer-by-Layer Nanoparticles
606   $aNucleic Acid
606   $aCoordination Chemistry
606   $aNanotechnology
606   $aSelf-assembly
615  0$aBiomaterials.
615  0$aNucleic acids.
615  0$aCoordination compounds.
615  0$aNanotechnology.
615  0$aSelf-assembly (Chemistry).
615  2$aNanotechnology.
615  2$aBiocompatible Materials.
615  2$aNucleic Acids.
615  2$aLayer-by-Layer Nanoparticles
615 14$aNucleic Acid.
615 24$aCoordination Chemistry.
615 24$aNanotechnology.
615 24$aSelf-assembly.
676   $a620.19
676   $a547.7
700   $aMori$b Keita$01631657
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910831014603321
997   $aUNINA