LEADER 03583nam 2200577 450 001 9910830922803321 005 20230421050622.0 010 $a1-283-28129-5 010 $a9786613281296 010 $a1-118-15060-0 010 $a1-118-15059-7 035 $a(CKB)2550000000060222 035 $a(EBL)818801 035 $a(OCoLC)757486965 035 $a(SSID)ssj0000550638 035 $a(PQKBManifestationID)11318748 035 $a(PQKBTitleCode)TC0000550638 035 $a(PQKBWorkID)10505845 035 $a(PQKB)10520045 035 $a(MiAaPQ)EBC818801 035 $a(EXLCZ)992550000000060222 100 $a20160815h19961996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBayesian methods and ethics in a clinical trial design /$fedited by Joseph B. Kadane 210 1$aNew York :$cJohn Wiley & Sons, Inc.,$d1996. 210 4$dİ1996 215 $a1 online resource (344 p.) 225 1 $aWiley Series in Probability and Statistics 300 $aDescription based upon print version of record. 311 $a0-471-84680-5 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aBayesian Methods and Ethics in a Clinical Trial Design; Contents; Preface; About the Authors; PART I MAJOR ISSUES; 1 Introduction; 2 Ethically Optimizing Clinical Trials; 3 Admissibility of Treatments; 4 Statistical Issues in the Analysis of Data Gathered in the New Designs; PART II TEST CASE: VERAPAMIL/NITROPRUSSIDE; 5 Introduction to the Verapamil/Nitroprusside Study; 6 The Mechanics of Conducting a Clinical Trial; 7 The Verapamil/Nitroprusside Study: Comments on ""The Mechanics of Conducting a Clinical Trial""; 8 Computational Aspects of the Verapamil/Nitroprusside Study; 9 Being an Expert 327 $a10 Issues of Statistical Design11 Operational History and Procedural Feasibility; 12 Verapamil versus Nitroprusside: Results of the Clinical Trial I; 13 Verapamil versus Nitroprusside: Results of the Clinical Trial II; PART III OTHER ISSUES; 14 The Law of Clinical Testing with Human Subjects: Legal Implications of the New and Existing Methodologies; 15 Commentary I on ""The Law of Clinical Testing with Human Subjects""; 16 Commentary II on ""The Law of Clinical Testing with Human Subjects""; 17 Author's Response to Commentaries I and II 327 $a18 Whether to Participate in a Clinical Trial: The Patient's ViewPART IV EPILOGUE; 19 Epilogue; NAME INDEX; SUBJECT INDEX 330 $aHow to conduct clinical trials in an ethical and scientifically responsible mannerThis book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involving a treatment for hypertension after open heart surgery--and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. 410 0$aWiley series in probability and statistics. 606 $aClinical trials$xMoral and ethical aspects 615 0$aClinical trials$xMoral and ethical aspects. 676 $a519.542 702 $aKadane$b Joseph B. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830922803321 996 $aBayesian methods and ethics in a clinical trial design$94067278 997 $aUNINA