LEADER 05238nam 22006254a 450 001 9910830892403321 005 20230617040507.0 010 $a1-280-23877-1 010 $a9786610238774 010 $a0-470-29820-0 010 $a0-470-86404-4 010 $a0-470-86405-2 035 $a(CKB)1000000000294581 035 $a(EBL)239023 035 $a(OCoLC)475950077 035 $a(SSID)ssj0000201678 035 $a(PQKBManifestationID)11179671 035 $a(PQKBTitleCode)TC0000201678 035 $a(PQKBWorkID)10246140 035 $a(PQKB)10866935 035 $a(MiAaPQ)EBC239023 035 $a(EXLCZ)991000000000294581 100 $a20040917d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMetallotherapeutic drugs and metal-based diagnostic agents$b[electronic resource] $ethe use of metals in medicine /$f[edited by] Marcel Gielen, Edward R.T. Tiekink 210 $aHoboken, N.J. $cWiley$dc2005 215 $a1 online resource (644 p.) 300 $aIncludes bibliographical references and index. 311 $a0-470-86403-6 327 $aMETALLOTHERAPEUTIC DRUGS AND METAL-BASED DIAGNOSTIC AGENTS; Contents; List of Contributors; Preface; 1 (3)Li Lithium Metallotherapeutics; 1.1 Introduction; 1.2 The Inorganic Chemistry of Lithium; 1.3 Biology of Lithium; 1.3.1 The history of lithium therapeutics; 1.3.2 Lithium and the body; 1.4 Targets of Lithium; 1.4.1 Glycogen synthase kinase-3; 1.4.2 Inositol phosphate signalling; 1.5 Lithium Therapeutics; 1.5.1 Bipolar disorder and schizophrenia; 1.5.2 Alzheimer's disease; 1.5.3 Ischemia (stroke); 1.5.4 Adverse effects; Acknowledgements; References 327 $a2 (5)B Boron Compounds as Therapeutic Drugs2.1 Boron Neutron Capture Therapy; 2.2 Classes of Boron Compounds for Potential Use in BNCT; 2.2.1 DNA binders; 2.2.2 Boron-containing amino acids and related peptides; 2.2.3 Boron-containing nucleic acid precursors; 2.3 Phosphates, Phosphonates and Phosphoramidates; 2.4 Amines; 2.5 Boron Analogues of Pyrophosphates; 2.6 Boronated Polyamines; 2.7 Carbohydrates; 2.8 Lipoproteins; 2.9 Lipids and Phospholipids; 2.10 Radiation Sensitizers; 2.11 Cyclic Thiourea Derivatives 327 $a2.12 Central Nervous System (CNS) Depressants: Promazines, Hydantoins and Barbiturates2.13 Hydantoins and Barbiturates; 2.14 Oligonucleotide Antisense Agents; 2.15 Hormones; 2.16 Liposomes; 2.17 Conclusions; Acknowledgements; References; 3 (12)Mg The Role of Magnesium as a Metallotherapeutic Drug; 3.1 Introduction; 3.2 Magnesium as a Drug; 3.2.1 Gestational hypertension, preeclampsia and eclampsia; 3.2.2 Asthma; 3.2.3 Stroke; 3.2.4 Acute myocardial infarction; 3.2.5 Arrhythmias; 3.2.6 Miscellaneous; References; 4 (13)Al Aluminum Metallotherapeutics; 4.1 Introduction; 4.2 Adjuvants; 4.2.1 Alum 327 $a4.2.2 Al(OH)(3)4.2.3 Aluminum phosphate; 4.3 Antacids; 4.3.1 Aluminum hydroxide; 4.3.2 Aluminum glycinate; 4.3.3 Peptic ulcer disease; 4.3.4 Bismuth aluminum carbonate; 4.3.5 Bismuth-magnesium-sodium alumino-silicate; 4.4 Phosphate Binders; 4.4.1 Basic aluminum carbonate; 4.4.2 Alumino-silicates; 4.5 Alginate Raft Formulations; 4.6 Blistering Diseases in the Elderly; 4.7 Metabolic Diseases and Aluminum; 4.8 Anti-malarial Substances; 4.9 Potential Aluminum Toxicity; 4.10 Conclusions; References; 5 (14)Si Biological Activity of Organosilicon Compounds; 5.1 Introduction 327 $a5.2 Organosilicon Modification5.2.1 O-, S- and N-Silylation; 5.2.2 C-Silylation; 5.3 Sila Analogues; 5.4 Specific Organosilicon Compounds; References; 6 (20)Ca The Role of Calcium as a Metallotherapeutic Drug; 6.1 Introduction; 6.2 Calcium Homeostasis; 6.3 Hormonal Regulation of Calcium Metabolism; 6.4 Optimal Amount of Dietary Calcium Intake and Benefits of Calcium Supplementation; 6.5 Osteoporosis; 6.6 Hypertension; 6.7 Hypertension in Pregnancy and Preeclampsia; 6.8 Colon Cancer; 6.9 Weight Control and Regulation of Body Fat; 6.10 Periodontal Disease; 6.11 Kidney Stones 327 $a6.12 Calcium Supplements: Side Effects 330 $aThere are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel me 606 $aMetals$xTherapeutic use 606 $aMetals$xDiagnostic use 615 0$aMetals$xTherapeutic use. 615 0$aMetals$xDiagnostic use. 676 $a615.23 676 $a615/.23 701 $aGielen$b M$g(Marcel),$f1938-$01608337 701 $aTiekink$b Edward R. T$0867117 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830892403321 996 $aMetallotherapeutic drugs and metal-based diagnostic agents$93997473 997 $aUNINA