LEADER 05289nam 2200649Ia 450 001 9910830879503321 005 20230607213147.0 010 $a1-280-36767-9 010 $a9786610367672 010 $a0-470-24631-6 010 $a0-471-46524-0 010 $a0-471-22042-6 035 $a(CKB)111056485585120 035 $a(EBL)468598 035 $a(OCoLC)52413035 035 $a(SSID)ssj0000227200 035 $a(PQKBManifestationID)11198779 035 $a(PQKBTitleCode)TC0000227200 035 $a(PQKBWorkID)10263375 035 $a(PQKB)11095379 035 $a(MiAaPQ)EBC468598 035 $a(EXLCZ)99111056485585120 100 $a20000719d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPrinciples and applications of asymmetric synthesis$b[electronic resource] /$fGuo-Qiang Lin, Yue-Ming Li, Albert S.C. Chan 210 $aNew York $cWiley-Interscience$dc2001 215 $a1 online resource (535 p.) 300 $aDescription based upon print version of record. 311 $a0-471-40027-0 320 $aIncludes bibliographical references and index. 327 $aPRINCIPLES AND APPLICATIONS OF ASYMMETRIC SYNTHESIS; CONTENTS; Preface; Abbreviations; 1 Introduction; 1.1 The Significance of Chirality and Stereoisomeric Discrimination; 1.2 Asymmetry; 1.2.1 Conditions for Asymmetry; 1.2.2 Nomenclature; 1.3 Determining Enantiomer Composition; 1.3.1 Measuring Specific Rotation; 1.3.2 The Nuclear Magnetic Resonance Method; 1.3.3 Some Other Reagents for Nuclear Magnetic Resonance Analysis; 1.3.4 Determining the Enantiomer Composition of Chiral Glycols or Cyclic Ketones; 1.3.5 Chromatographic Methods Using Chiral Columns 327 $a1.3.6 Capillary Electrophoresis with Enantioselective Supporting Electrolytes1.4 Determining Absolute Configuration; 1.4.1 X-Ray Diffraction Methods; 1.4.2 Chiroptical Methods; 1.4.3 The Chemical Interrelation Method; 1.4.4 Prelog's Method; 1.4.5 Horeau's Method; 1.4.6 Nuclear Magnetic Resonance Method for Relative Configuration Determination; 1.5 General Strategies for Asymmetric Synthesis; 1.5.1 ""Chiron"" Approaches; 1.5.2 Acyclic Diastereoselective Approaches; 1.5.3 Double Asymmetric Synthesis; 1.6 Examples of Some Complicated Compounds 327 $a1.7 Some Common Definitions in Asymmetric Synthesis and Stereochemistry1.8 References; 2 a-Alkylation and Catalytic Alkylation of Carbonyl Compounds; 2.1 Introduction; 2.2 Chirality Transfer; 2.2.1 Intra-annular Chirality Transfer; 2.2.2 Extra-annular Chirality Transfer; 2.2.3 Chelation-Enforced Intra-annular Chirality Transfer; 2.3 Preparation of Quaternary Carbon Centers; 2.4 Preparation of a-Amino Acids; 2.5 Nucleophilic Substitution of Chiral Acetal; 2.6 Chiral Catalyst-Induced Aldehyde Alkylation: Asymmetric Nucleophilic Addition 327 $a2.7 Catalytic Asymmetric Additions of Dialkylzinc to Ketones: Enantioselective Formation of Tertiary Alcohols2.8 Asymmetric Cyanohydrination; 2.9 Asymmetric a-Hydroxyphosphonylation; 2.10 Summary; 2.11 References; 3 Aldol and Related Reactions; 3.1 Introduction; 3.2 Substrate-Controlled Aldol Reaction; 3.2.1 Oxazolidones as Chiral Auxiliaries: Chiral Auxiliary-Mediated Aldol-Type Reactions; 3.2.2 Pyrrolidines as Chiral Auxiliaries; 3.2.3 Aminoalcohols as the Chiral Auxiliaries; 3.2.4 Acylsultam Systems as the Chiral Auxiliaries; 3.2.5 a-Silyl Ketones; 3.3 Reagent-Controlled Aldol Reactions 327 $a3.3.1 Aldol Condensations Induced by Chiral Boron Compounds3.3.2 Aldol Reactions Controlled by Corey's Reagents; 3.3.3 Aldol Condensations Controlled by Miscellaneous Reagents; 3.4 Chiral Catalyst-Controlled Asymmetric Aldol Reaction; 3.4.1 Mukaiyama's System; 3.4.2 Asymmetric Aldol Reactions with a Chiral Ferrocenylphosphine-Gold(I) Complex; 3.4.3 Asymmetric Aldol Reactions Catalyzed by Chiral Lewis Acids; 3.4.4 Catalytic Asymmetric Aldol Reaction Promoted by Bimetallic Catalysts: Shibasaki's System; 3.5 Double Asymmetric Aldol Reactions; 3.6 Asymmetric Allylation Reactions 327 $a3.6.1 The Roush Reaction 330 $aAsymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students.Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as ca 606 $aAsymmetric synthesis 606 $aOrganic compounds$xSynthesis 615 0$aAsymmetric synthesis. 615 0$aOrganic compounds$xSynthesis. 676 $a547.2 676 $a547/.2 700 $aLin$b Guo-Qiang$f1943-$066570 701 $aLi$b Yue-Ming$f1966-$0897405 701 $aChan$b Albert Sun-Chi$f1950-$0897406 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830879503321 996 $aPrinciples and applications of asymmetric synthesis$92004944 997 $aUNINA