LEADER 03750nam 22006374a 450 001 9910830862403321 005 20170810183550.0 010 $a1-280-23859-3 010 $a9786610238590 010 $a0-470-02052-0 010 $a0-470-02051-2 035 $a(CKB)1000000000356165 035 $a(EBL)239005 035 $a(SSID)ssj0000114281 035 $a(PQKBManifestationID)11143086 035 $a(PQKBTitleCode)TC0000114281 035 $a(PQKBWorkID)10102281 035 $a(PQKB)11686337 035 $a(MiAaPQ)EBC239005 035 $a(OCoLC)85820824 035 $a(PPN)137624662 035 $a(EXLCZ)991000000000356165 100 $a20030925d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBrain energetics and neuronal activity$b[electronic resource] $eapplications to fMRI and medicine /$feditors, R.G. Shulman and D.L. Rothman 210 $aChichester, West Sussex, England ;$aHoboken, N.J. $cJ. Wiley$dc2004 215 $a1 online resource (335 p.) 300 $aDescription based upon print version of record. 311 $a0-470-84720-4 320 $aIncludes bibliographical references and index. 327 $aBrain Energetics and Neuronal Activity; Contents; Contributors; Foreword; Section A: Background; 1 Introduction; 2 Energy Metabolism in Neural Tissues in vivo at Rest and in Functionally Altered States; 3 Techniques-MRS, fMRI, (13)C NMR, Indirect Detection of (13)C; 4 Metabolic Modeling Analysis of Brain Metabolism; Section B: Neuroenergetics and Activity; 5 Cerebral Energetics and Neurotransmitter Fluxes; 6 NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways; 7 Neural Energy Consumption and the Representation of Mental Events 327 $a8 Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO(2)) using (17)O NMR Approach at Ultrahigh Field9 Deriving Changes in CMR(O2) from Calibrated fMRI; 10 Relationship between CMR(O2) and Neuronal Activity; Section C: Clinical Beginnings; 11 NMR Studies of Bioenergetic Impairment in Human Epilepsy; 12 MRS Studies of the Role of Altered Glutamate and GABA Neurotransmitter Metabolism in the Pathophysiology of Epilepsy; 13 The Role of Altered Energetics of Neurotransmitter Systems in Psychiatric Disease; Section D: Brain and Mind 327 $a14 Long-term Memory: Do Incremental Signals Reflect Engagement of Cognitive Processes?15 Using fMRI to Study the Mind and Brain; 16 Brain and Mind: an NMR Perspective; 17 The Role of the NMR Baseline Signal in the Study of Consciousness: the Restless Brain; Index 330 $aThis book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders.Novel and potentially controversialWill inspire future research directions 606 $aBrain$xMetabolism 606 $aEnergy metabolism 606 $aBrain$xPathophysiology 606 $aBrain$xMagnetic resonance imaging 615 0$aBrain$xMetabolism. 615 0$aEnergy metabolism. 615 0$aBrain$xPathophysiology. 615 0$aBrain$xMagnetic resonance imaging. 676 $a612.82 701 $aShulman$b R. G$g(Robert Gerson)$01611280 701 $aRothman$b D. L$g(Douglas L.)$01611281 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830862403321 996 $aBrain energetics and neuronal activity$94049959 997 $aUNINA