LEADER 03520nam 2200625 450 001 9910830861703321 005 20170821194048.0 010 $a1-118-70530-0 010 $a1-118-70504-1 010 $a1-118-70498-3 035 $a(CKB)3710000000179984 035 $a(EBL)1732116 035 $a(SSID)ssj0001261732 035 $a(PQKBManifestationID)11729127 035 $a(PQKBTitleCode)TC0001261732 035 $a(PQKBWorkID)11205839 035 $a(PQKB)10320184 035 $a(OCoLC)871966217 035 $a(MiAaPQ)EBC1732116 035 $a(DLC) 2014009508 035 $a(PPN)219903301 035 $a(EXLCZ)993710000000179984 100 $a20140902h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug transporters $emolecular characterization and role in drug disposition /$fedited by Guofeng You, Marilyn E. Morris 205 $a2nd ed. 210 1$aHoboken, New Jersey :$cJohn Wiley & Sons, Inc.,$d2014. 210 4$dİ2014 215 $a1 online resource (2143 p.) 225 1 $aWiley Series in Drug Discovery and Development 300 $aDescription based upon print version of record. 311 $a1-322-10863-3 311 $a1-118-48993-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aOverview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development. 330 $a This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approach 410 0$aWiley series in drug discovery and development. 606 $aCarrier proteins$vLaboratory manuals 606 $aDrugs$xResearch 615 0$aCarrier proteins 615 0$aDrugs$xResearch. 676 $a571.64 702 $aYou$b Guofeng 702 $aMorris$b Marilyn E. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830861703321 996 $aDrug Transporters$91114930 997 $aUNINA