LEADER 03477nam 22006134a 450 001 9910830835903321 005 20230721003732.0 010 $a1-281-83126-3 010 $a9786611831264 010 $a0-470-39927-9 010 $a0-470-39926-0 035 $a(CKB)1000000000557011 035 $a(EBL)362114 035 $a(OCoLC)476191902 035 $a(SSID)ssj0000218737 035 $a(PQKBManifestationID)11175958 035 $a(PQKBTitleCode)TC0000218737 035 $a(PQKBWorkID)10221130 035 $a(PQKB)10279419 035 $a(MiAaPQ)EBC362114 035 $a(EXLCZ)991000000000557011 100 $a20080403d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPathway analysis for drug discovery$b[electronic resource] $ecomputational infrastructure and applications /$fedited by Anton Yuryev 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2008 215 $a1 online resource (332 p.) 225 1 $aWiley series on technologies for the pharmaceutical industry 300 $aDescription based upon print version of record. 311 $a0-470-10705-7 320 $aIncludes bibliographical references and index. 327 $aPATHWAY ANALYSIS FOR DRUG DISCOVERY; CONTENTS; Preface; Contributors; 1 Introduction to Pathway Analysis; 2 Software Infrastructure and Data Model for Pathway Analysis; 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks; 4 Algorithmic Basis for Pathway Visualization; 5 Pathway Analysis of High-Throughput Experimental Data; 6 Integrative Pathway Analysis of Disease Molecular Data; 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise; 8 Mammalian Proteome and Toxicant Network Analysis 327 $a9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example10 Impact of Chemistry Information on Pathway Analysis; 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks; 12 An Adaptive System Model of the Yeast Glucose Sensor System; 13 Present and Future of Pathway Analysis in Drug Discovery; Index 330 $aThis book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in rela 410 0$aWiley series on technologies for the pharmaceutical industry. 606 $aDrug development$xData processing 606 $aDNA microarrays$xData processing 606 $aComputational biology 615 0$aDrug development$xData processing. 615 0$aDNA microarrays$xData processing. 615 0$aComputational biology. 676 $a615.19 676 $a615/.190285 701 $aYuryev$b Anton$01627913 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830835903321 996 $aPathway analysis for drug discovery$93964741 997 $aUNINA