LEADER 05341nam 22006734a 450 001 9910830825603321 005 20230617040751.0 010 $a1-280-51997-5 010 $a9786610519972 010 $a3-527-60370-0 010 $a3-527-60473-1 035 $a(CKB)1000000000328769 035 $a(EBL)482384 035 $a(OCoLC)68666267 035 $a(SSID)ssj0000211943 035 $a(PQKBManifestationID)11201946 035 $a(PQKBTitleCode)TC0000211943 035 $a(PQKBWorkID)10136317 035 $a(PQKB)11453808 035 $a(MiAaPQ)EBC482384 035 $a(EXLCZ)991000000000328769 100 $a20040720d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNonlinear physics of DNA$b[electronic resource] /$fLudmila V. Yakushevich 205 $a2nd ed. 210 $aWeinheim $cWiley-VCH$dc2004 215 $a1 online resource (208 p.) 300 $aDescription based upon print version of record. 311 $a3-527-40417-1 320 $aIncludes bibliographical references (p. [175]-187) and index. 327 $aNonlinear Physics of DNA; Contents; Preface to the First Edition; Preface to the Second Edition; Dedication; 1 DNA Structure; 1.1 Chemical Composition and Primary Structure; 1.2 Spatial Geometry and Secondary Structure; 1.3 Forces Stabilizing the Secondary DNA Structure; 1.3.1 Hydrogen Interactions; 1.3.2 Stacking Interactions; 1.3.3 Long-range Intra- and Inter-backbone Forces; 1.3.4 Electrostatic Field of DNA; 1.4 Polymorphism; 1.5 Tertiary Structure; 1.5.1 Superhelicity; 1.5.2 Structural Organization in Cells; 1.6 Approximate Models of DNA Structure; 1.6.1 General Comments 327 $a1.6.2 Hierarchy of Structural Models1.7 Experimental Methods of Studying DNA Structure; 2 DNA Dynamics; 2.1 General Picture of the DNA Internal Mobility; 2.2 Twisting and Bending Motions; 2.3 Dynamics of the Bases; 2.3.1 Equilibrium State; 2.3.2 Possible Motions of the Bases; 2.4 Dynamics of the Sugar-Phosphate Backbone; 2.4.1 Equilibrium State; 2.4.2 Possible Motions of the Sugar-Phosphate Backbone; 2.5 Conformational Transitions; 2.5.1 B-->A Transition; 2.5.2 B-->Z Transition; 2.6 Motions Associated with Local Strands Separation; 2.6.1 Base-pair Opening Due to Rotations of Bases 327 $a2.6.2 Transverse Displacements in Strands2.7 Approximate Models of DNA Dynamics; 2.7.1 The Main Principles of Modeling; 2.7.2 Hierarchy of Dynamical Models; 2.8 Experimental Methods for Studying DNA Dynamics; 2.8.1 Raman Scattering; 2.8.2 Neutron Scattering; 2.8.3 Infrared Spectroscopy; 2.8.4 Hydrogen-Deuterium (-Tritium) Exchange; 2.8.5 Microwave Absorption; 2.8.6 NMR; 2.8.7 Charge-transfer Experiments; 2.8.8 Single Molecule Experiments; 3 DNA Function; 3.1 Physical Aspects of DNA Function; 3.2 Intercalation; 3.3 DNA-Protein Recognition; 3.4 Gene Expression; 3.5 Regulation of Gene Expression 327 $a3.6 Replication4 Linear Theory of DNA; 4.1 The Main Mathematical Models; 4.1.1 Linear Rod-like Model; 4.1.1.1 Longitudinal and Torsional Dynamics: Discrete Case; 4.1.1.2 Longitudinal and Torsional Dynamics: Continuous Case; 4.1.1.3 Bending Motions; 4.1.2 Linear Double Rod-like Model; 4.1.2.1 Discrete Case; 4.1.2.2 Continuous Case; 4.1.3 Linear Models of Higher Levels; 4.1.3.1 The Third-Level Models; 4.1.3.2 The Fourth-level (Lattice) Models; 4.2 Statistics of Linear Excitations; 4.2.1 Phonons in the Rod-like Model; 4.2.1.1 General Solution of the Model Equations 327 $a4.2.1.2 Secondary Quantum Representation4.2.1.3 Correlation Functions; 4.2.2 Phonons in the Double Rod-like Model; 4.2.2.1 General Solution of the Model Equations; 4.2.2.2 Secondary Quantum Representation; 4.2.2.3 Correlation Functions; 4.2.3 Phonons in the Higher-level Models; 4.3 Scattering Problem; 4.3.1 Scattering by 'Frozen' DNA; 4.3.2 Elastic Scattering; 4.3.3 Inelastic Scattering; 4.4 Linear Theory and Experiment; 4.4.1 Fluorescence Depolarization; 4.4.2 Low-frequency Spectra: Neutron Scattering, Infrared scattering, Raman Scattering, Speed of Sound 327 $a5 Nonlinear Theory of DNA: Ideal Dynamical Models 330 $aThe first edition of this book was the first on the physics of DNA to go beyond the simple (simplified) 'linear' approach, and it has since been found that the inclusion of nonlinear effects leads to a significantly improved interpretation of experimental data. This new edition naturally retains this approach, but has been completely revised, updated and expanded to cover recent developments.Beginning with introductory chapters on DNA structure and dynamics, the book also includes a comparison between linear and nonlinear approaches to the DNA molecule, a chapter devoted to the statistics 606 $aDNA$xStructure 606 $aDNA$xConformation 606 $aNonlinear mechanics 606 $aBiophysics 615 0$aDNA$xStructure. 615 0$aDNA$xConformation. 615 0$aNonlinear mechanics. 615 0$aBiophysics. 676 $a572.86 676 $a572.8633 700 $aI?Akushevich$b L. V$g(Li?udmila Vladimirovna)$0772177 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830825603321 996 $aNonlinear physics of DNA$91576269 997 $aUNINA