LEADER 04712nam 22006254a 450 001 9910830812503321 005 20170815110459.0 010 $a1-280-90025-3 010 $a9786610900251 010 $a0-470-13186-1 010 $a0-470-13185-3 035 $a(CKB)1000000000355452 035 $a(EBL)297263 035 $a(OCoLC)476071312 035 $a(SSID)ssj0000141553 035 $a(PQKBManifestationID)11911822 035 $a(PQKBTitleCode)TC0000141553 035 $a(PQKBWorkID)10090701 035 $a(PQKB)10781486 035 $a(MiAaPQ)EBC297263 035 $a(PPN)137627181 035 $a(EXLCZ)991000000000355452 100 $a20070226d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug discovery research$b[electronic resource] $enew frontiers in the post-genomic era /$fedited by Ziwei Huang 210 $aHoboken, N.J. $cWiley-Interscience$dc2007 215 $a1 online resource (560 p.) 300 $aDescription based upon print version of record. 311 $a0-471-67200-9 320 $aIncludes bibliographical references and index. 327 $aMolecular docking and structure-based design / P. Therese Lang ... [et al.] -- Recent advances in drug discovery research using structure-based virtual screening techniques : examples of success for diverse protein targets / Sutapa Ghosh ... [et al.] -- Virtual screening in drug discovery / Malcolm J. McGregor, Zhaowen Luo, and Xuliang Jiang -- Computer-aided drug design / Grace Shiahuy Chen and Ji-Wang Chern -- Focused library design based on hit and target structures : method and application in drug discovery / Weiliang Zhu ... [et al.] -- 327 $aBeyond natural products : synthetic analogs of bryostatin 1 / Paul A. Wender ... [et al.] -- The promises and pitfalls of small-molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG) / Amanda C. Nottbohm and Paul J. Hergenrother -- Cyclic ADP-ribose analogues with minimal structure : synthesis and calcium-release activity / Lihe Zhang and Andreas H. Guse -- Evaluation of neuroimmunophilin ligands / Junhai Xiao, Aihua Nie, and Song Li -- Chiral drugs and the associated asymmetric synthesis / Jiange Zhang and Guoqiang Lin -- 327 $aAlpha-helix mimetics in drug discovery / Hang Yin, Gui-In Lee, and Andrew D. Hamilton -- Basic and translational research of chemokine ligands and receptors and development of novel therapeutics / Won-Tak Choi ... [et al.] -- Research progress in protein post-translational modification / Jia Hu, Yanting Guo, and Yanmei Li -- Controlled release of antibiotics encapsulated in nanoporous sol-gel materials with tunable pore parameters / Houping Yin, Laura Zheng, and Yen Wei -- Retinoic acid and arsenic trioxide treatment in acute promyelocytic leukemia : a model of oncoprotein targeted therapy / Jian-Hua Tong, Sai-Juan Chen, and Zhu Chen. 327 $a2-chlorodeoxyadenosine (cladribine) : rational development of a novel chemotherapeutic agent / Howard B. Cottam and Dennis A. Carson -- Apoptosis-based drug discovery for cancer / John C. Reed ... [et al.] -- Mechanism-based development of memantine as a therapeutic agent in treating Alzheimer's disease and other neurologic disorders : low-affinity, uncompetitive antagonism with fast off-rate / Huei-Sheng Vincent Chen and Stuart A. Lipton -- Bridging bench to clinic : roles of animal models for post-genomics drug discovery on metabolic diseases / Chi-Wai Wong and Ling Chen -- Stem cell research and applications for human therapies / Prithi Rajan ... [et al.]. 330 $aPost Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era.Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognitionIncludes discussion on topics such as: computer-aided ligan 606 $aDrugs$xDesign 606 $aBiopharmaceutics 606 $aPharmaceutical chemistry 615 0$aDrugs$xDesign. 615 0$aBiopharmaceutics. 615 0$aPharmaceutical chemistry. 676 $a615.19 676 $a615/.19 701 $aHuang$b Ziwei$f1965-$01611952 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830812503321 996 $aDrug discovery research$93940450 997 $aUNINA