LEADER 02330oam 2200397 450 001 9910830800603321 005 20230629234159.0 010 $a3-527-82673-4 010 $a3-527-82674-2 010 $a3-527-82675-0 035 $a(CKB)4100000011248755 035 $a(MiAaPQ)EBC6465880 035 $a(EXLCZ)994100000011248755 100 $a20210629d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aLong-lived proteins in human aging and disease /$fedited by Roger J.W. Truscott 210 1$aWeinheim, Germany :$cWiley-VCH,$d[2021] 210 4$d©2021 215 $a1 online resource (x, 209 pages) $cillustrations 311 $a3-527-34728-3 330 $a"While most proteins in the human body are short-lived and are constantly being regenerated, this is not true for all. A significant fraction of proteins in long-lived cells such as nerve cells are likewise long-lived and will age over time by accumulating damage and other modifications. Scientists are only beginning to understand how this aging of long-lived proteins contributes to age-dependent diseases such as dementia and cancer Divided into six major sections, this comprehensive overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. Analytical methods to study protein half-life and the accumulation of modifications are presented, followed by several examples of long-lived proteins found in humans and other organisms. Next, the molecular mechanisms of aging on the protein level are described, in particular the most common side chain modifications, followed by a discussion of the consequences of protein aging on cellular and organ function. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed"--$cProvided by publisher. 606 $aAging$xMolecular aspects 615 0$aAging$xMolecular aspects. 676 $a612.67 702 $aTruscott$b Roger J. W. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910830800603321 996 $aLong-lived proteins in human aging and disease$93972602 997 $aUNINA