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010   $a1-282-90488-4
010   $a9786612904882
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100   $a20100804d2011      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aRNA interference$b[electronic resource] $eapplication to drug discovery and challenges to pharmaceutical development /$fedited by Paul H. Johnson
210   $aHoboken, N.J. $cWiley$dc2011
215   $a1 online resource (330 p.)
300   $aDescription based upon print version of record.
311   $a0-471-77151-1 
320   $aIncludes bibliographical references and index.
327   $aRNA INTERFERENCE; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; I BIOLOGY OF RNA INTERFERENCE; 1 RNA INTERFERENCE: WHAT IS IT?; 2 NUCLEIC ACIDS AS REGULATORY MOLECULES; 3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION; 4 GENOME SCANNING BY RNA INTERFERENCE; II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS; 5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS; 6 SIRNA DELIVERY VEHICLES; 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES; 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES; INDEX; Color Plate
330   $aRNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
606   $aDrug development
606   $aRNA
606   $aSmall interfering RNA
615  0$aDrug development.
615  0$aRNA.
615  0$aSmall interfering RNA.
676   $a572.8/8
676   $a572.88
701   $aJohnson$b Paul H.$f1943-$01633049
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910830800303321
996   $aRNA interference$93972601
997   $aUNINA