LEADER 05307nam 2200649 450 001 9910830798603321 005 20180504123513.0 010 $a1-282-01046-8 010 $a9786612010460 010 $a3-527-60850-8 010 $a3-527-61445-1 035 $a(CKB)1000000000377309 035 $a(EBL)481710 035 $a(OCoLC)85821080 035 $a(SSID)ssj0000167843 035 $a(PQKBManifestationID)11170237 035 $a(PQKBTitleCode)TC0000167843 035 $a(PQKBWorkID)10178428 035 $a(PQKB)11641277 035 $a(MiAaPQ)EBC481710 035 $a(PPN)199229058 035 $a(EXLCZ)991000000000377309 100 $a20160816h20062006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHandbook of meningococcal disease $einfection biology, vaccination, clinical management /$fedited by Matthias Frosch and Martin C. J. Maiden 210 1$aWeinheim, [Germany] :$cWiley-VCH Verlag GmbH & Co. KGaA,$d2006. 210 4$dİ2006 215 $a1 online resource (594 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31260-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aHandbook of Meningococcal Disease; Contents; Preface; Foreword; List of Contributors; Color Plates; 1 Historical Aspects; 1.1 The Origins of Meningococcal Disease; 1.2 The 19th Century; 1.3 From 1900 to 1920; 1.4 From 1921 to 1939; 1.5 From World War II to 1960 - Epidemiology; 1.6 From 1961 to 2005; 1.7 Conclusion; References; Part I Epidemiology of Meningococcal Disease; 2 The Population Biology of Neisseria meningitidis: Implications for Meningococcal Disease, Epidemiology and Control; 2.1 Introduction: The Meningococcus, an Enigmatic Pathogen 327 $a2.1.1 The Global Burden of Meningococcal Disease2.1.2 Paradoxes Arising from Meningococcal Natural History; 2.2 Meningococcal Diversity and its Consequences; 2.2.1 Genetic and Antigenic Diversity; 2.2.2 Structure Within Meningococcal Populations - The Clonal Complex; 2.3 Mechanisms of Diversification and Structuring in Meningococcal Populations; 2.3.1 Mutation and Recombination in Bacterial Evolution; 2.3.2 Evidence for Recombination in Meningococcal Populations; 2.4 Meningococcal Genotypes in Carriage and Disease; 2.4.1 The Hyperinvasive Lineages 327 $a2.5 Global Epidemiology of Meningococcal Disease2.5.1 The Group A Pandemics; 2.5.2 The ST-11 (ET-37) Complex Epidemics; 2.5.3 The ST-32 (ET-5) Pandemic; 2.5.4 The ST-41/44 Complex (Lineage 3); 2.5.5 Other Complexes; 2.6 Conclusions: Implications of Meningococcal Population Biology for Disease Control; References; 3 Methods for Typing of Meningococci; 3.1 Introduction; 3.2 Phenotypic Typing Methods; 3.3 Serological Typing Methods; 3.3.1 Serogrouping of Meningococci; 3.3.2 Serotyping and Serosubtyping; 3.4 Immunotyping; 3.5 Multilocus Enzyme Electrophoresis; 3.6 Genetic Characterization 327 $a3.6.1 Antigen Gene PCR and Sequencing for Meningococcal Typing3.6.2 Genogrouping (PCR-based Designation of Group); 3.6.3 Genotyping and Genosubtyping - porB and porA Sequencing; 3.6.4 FetA; 3.6.5 Multilocus Sequence Typing; 3.6.6 Variable-number Tandem Repeats; 3.6.7 Pulsed Field Gel Electrophoresis; 3.6.8 Databases; 3.7 Conclusion; References; 4 Antibiotic Resistance; 4.1 Introduction; 4.2 Testing Antibiotics Against N. meningitidis; 4.2.1 Methodological Issues in N. meningitidis Susceptibility Testing; 4.2.1.1 The "Invasion" of the Etest; 4.2.1.2 The Breakpoint Issue 327 $a4.3 Clinical Impact and Spread of Antibiotic Resistance in Meningococcal Disease4.3.1 Antibiotic Resistance in the Chemoprophylaxis of Meningococcal Disease; 4.3.2 Antibiotic Resistance in the Treatment of Meningococcal Disease; 4.3.2.1 Penicillin; 4.3.2.2 Chloramphenicol; 4.3.2.3 Quinolones; 4.4 Are There New Drugs or New Strategies on the Horizon?; 4.5 Molecular Tools for Definition of Antimicrobial Susceptibility in N. meningitidis; References; Part II Genetics and Genomics of the Meningococcus; 5 Neisseria meningitidis Genome Sequencing Projects; 5.1 Introduction 327 $a5.2 The Genomes of Neisseria meningitidis 330 $aA comprehensive overview of recent advances, from current basic research and epidemiology, to novel therapeutic strategies and clinical management. Here, the leading scientists who have made major advances in the field provide up-to-date reviews and describe their current knowledge and concepts.As such, this is the first volume to summarize the implications of the meningococcus genome-sequencing project, emphasizing the novel strategies in vaccine development. Following a look at the history, the authors go on to treat the epidemiology of meningococcal disease, as well as the genetics, str 606 $aMeningitis 606 $aNeisseria meningitidis 615 0$aMeningitis. 615 0$aNeisseria meningitidis. 676 $a616.8/2 676 $a616.82 702 $aFrosch$b Matthias 702 $aMaiden$b Martin C. J. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830798603321 996 $aHandbook of meningococcal disease$93972588 997 $aUNINA