LEADER 05199nam 2200637Ia 450 001 9910830768503321 005 20230617021300.0 010 $a1-280-52052-3 010 $a9786610520527 010 $a3-527-60543-6 010 $a3-527-60238-0 035 $a(CKB)1000000000019330 035 $a(EBL)482326 035 $a(OCoLC)64625120 035 $a(SSID)ssj0000149055 035 $a(PQKBManifestationID)11136657 035 $a(PQKBTitleCode)TC0000149055 035 $a(PQKBWorkID)10237987 035 $a(PQKB)11596085 035 $a(MiAaPQ)EBC482326 035 $a(EXLCZ)991000000000019330 100 $a20040601d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aErythropoietin$b[electronic resource] $eblood, brain and beyond /$fArthur J. Sytkowski 210 $aWeinheim $cWiley-VCH$d2004 215 $a1 online resource (240 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30495-9 320 $aIncludes bibliographical references and index. 327 $aErythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis 327 $a2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein? 327 $a3.3.2 The 3 ? Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production 327 $a4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo 327 $a5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways 327 $a6.2.1 Phosphorylation of the Erythropoietin Receptor 330 $aThe use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The boo 606 $aErythropoietin 606 $aErythropoietin$xPhysiological effect 606 $aErythropoietin$xTherapeutic use 615 0$aErythropoietin. 615 0$aErythropoietin$xPhysiological effect. 615 0$aErythropoietin$xTherapeutic use. 676 $a612.111 676 $a615.39 700 $aSytkowski$b Arthur J$01607766 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830768503321 996 $aErythropoietin$93934174 997 $aUNINA