LEADER 00919nam a22002411i 4500 001 991002285709707536 005 20030523114954.0 008 030925s1883 it |||||||||||||||||ita 035 $ab1226765x-39ule_inst 035 $aARCHE-031522$9ExL 040 $aBiblioteca Interfacoltà$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a945.753 100 1 $aStampacchia, Gioacchino$0453032 245 10$aGallipoli :$bche fu, che è, che sarà per essere : ricordo /$cGioacchino Stampacchia 260 $aGallipoli :$bTip. municipale,$c1883 300 $a1 v. ;$c21 cm 650 4$aGallipoli$xStoria 907 $a.b1226765x$b02-04-14$c08-10-03 912 $a991002285709707536 945 $aLE002 Misc. I E 17/16$g1$iLE002-S.i.-00090$lle002$o-$pE0.00$q-$rn$so $t0$u0$v0$w0$x0$y.i12658686$z08-10-03 996 $aGallipoli$9152485 997 $aUNISALENTO 998 $ale002$b08-10-03$cm$da $e-$fita$git $h0$i1 LEADER 02531oam 2200649I 450 001 9910779696903321 005 20230421051134.0 010 $a1-136-31382-6 010 $a0-203-04448-7 010 $a1-299-45843-2 010 $a1-136-31375-3 024 7 $a10.4324/9780203044483 035 $a(CKB)2550000001018818 035 $a(EBL)1166347 035 $a(SSID)ssj0000855990 035 $a(PQKBManifestationID)11471342 035 $a(PQKBTitleCode)TC0000855990 035 $a(PQKBWorkID)10805489 035 $a(PQKB)10523424 035 $a(MiAaPQ)EBC1166347 035 $a(Au-PeEL)EBL1166347 035 $a(CaPaEBR)ebr10684778 035 $a(CaONFJC)MIL477093 035 $a(OCoLC)839304437 035 $a(FINmELB)ELB134554 035 $a(EXLCZ)992550000001018818 100 $a20180706d1998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDemise of the British empire in the Middle East $eBritain's responses to nationalist movements, 1943-55 /$fedited by Michael J. Cohen and Martin Kolinsky 210 1$aLondon ;$aPortland, Or. :$cFrank Cass,$d1998. 215 $a1 online resource (473 p.) 300 $aDescription based upon print version of record. 311 $a0-7146-4477-3 311 $a0-7146-4804-3 320 $aIncludes bibliographical references and index. 327 $apt. 1. The effect of war on the Middle East -- pt. 2. Aspects of Arab nationalism -- pt. 3. Egypt in conflict with Britain -- pt. 4. Degrees of accommodation with Britain. 330 $aBritain emerged from World War II dependent economically and militarily upon the US. Egypt was the hub of Britain's imperial interests in the Middle East, but her inability to maintain a large garrison there was clear to the indigenous peoples. These essays track the decline of the empire. 606 $aNationalism$zMiddle East 607 $aGreat Britain$xForeign relations$zMiddle East 607 $aMiddle East$xForeign relations$zGreat Britain 607 $aGreat Britain$xPolitics and government$y1945- 607 $aMiddle East$xPolitics and government$y1945- 615 0$aNationalism 676 $a327.41056 701 $aCohen$b Michael Joseph$f1940-$01379468 701 $aKolinsky$b Martin$0247364 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910779696903321 996 $aDemise of the British empire in the Middle East$93800680 997 $aUNINA LEADER 05457nam 2200685Ia 450 001 9910830763503321 005 20170809170508.0 010 $a1-282-13817-0 010 $a9786612138171 010 $a0-470-74355-7 010 $a0-470-74356-5 035 $a(CKB)1000000000719723 035 $a(EBL)427972 035 $a(OCoLC)437111545 035 $a(SSID)ssj0000354170 035 $a(PQKBManifestationID)11277468 035 $a(PQKBTitleCode)TC0000354170 035 $a(PQKBWorkID)10302772 035 $a(PQKB)10891865 035 $a(MiAaPQ)EBC427972 035 $a(PPN)152565043 035 $a(EXLCZ)991000000000719723 100 $a20081231d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe epigenetics of autoimmune diseases$b[electronic resource] /$fedited by Moncef Zouali 210 $aChichester ;$aHoboken, NJ $cWiley-Blackwell$d2009 215 $a1 online resource (473 p.) 300 $aDescription based upon print version of record. 311 $a0-470-75861-9 320 $aIncludes bibliographical references and index. 327 $aThe Epigenetics of Autoimmune Diseases; Contents; Preface; Contributors; PART I Transcription Factors: Partners of Immune Tolerance to Self; 1 Transcriptional regulation of T cell tolerance; 1.1 Introduction; 1.2 T cell anergy; 1.3 Ca2+/calcineurin/NFAT signalling in T cell anergy; 1.4 Transcriptional programme of T cell anergy; 1.5 Transcriptional repression in T cell anergy: epigenetic modification of the Il2 promoter; 1.6 Regulatory T cells; 1.7 Transcriptional control of Treg development and function; References; 2 Epigenetic regulation of Foxp3 expression in regulatory T cells 327 $a2.1 Introduction2.2 Naturally occurring CD25+ CD4+ Tregs; 2.3 The transcription factor FOXP3: determining Treg function and identity; 2.4 Molecular regulation of FOXP3; 2.5 Tregs as a stable lineage: indications of epigenetic imprinting; 2.6 Induced Tregs: stable suppressors or transient immuno-modulators?; 2.7 Conclusions; References; 3 The role of NF-kB in central tolerance; 3.1 Introduction; 3.2 Canonical and alternative NF-kB pathways; 3.3 Thymic stroma and central tolerance; 3.4 NF-kB and regulatory T cell development; 3.5 NF-kB and thymocyte positive and negative selection 327 $a3.6 Conclusions and perspectives3.7 Acknowledgement; References; 4 The role of Act1 in the control of autoimmunity; 4.1 Introduction; 4.2 Autoimmunity and autoimmune mouse models; 4.3 Molecular mechanisms of autoimmunity; 4.4 Act1: a modulator of autoimmunity; 4.5 Conclusions; References; 5 Regulation of T cell anergy and escape from regulatory T cell suppression by Cbl-b; 5.1 Introduction; 5.2 Mechanisms of T cell tolerance induction; 5.3 Molecular establishment of T cell anergy; 5.4 Ubiquitin E3 ligases in T cell tolerance; 5.5 Molecular function and regulation of Cbl-b 327 $a5.6 Physiological relevance of Cbl-b5.7 The role of Cbl-b in T cell tolerance; 5.8 Deregulation of Cbl-b in disease; 5.9 Therapeutic potential of Cbl-b in tumour immunity; 5.10 Implications for autoimmune disease; References; 6 Indoleamine 2,3-dioxygenase: transcriptional regulation and autoimmunity; 6.1 Introduction; 6.2 L-Trp degradation along the kynurenine pathway and immune functions of IDO; 6.3 IDO immunobiology and therapeutic intervention; 6.4 Transcriptional regulation of the IDO-encoding gene; 6.5 Impaired IDO activity and loss of tolerance in autoimmune diseases 327 $a6.6 IDO-based therapies for autoimmune disease6.7 Acknowledgement; References; PART II Stress Responses that Break Immune Silence; 7 Chromatin modifications, oxidative stress and nucleosome autoantibodies; 7.1 Introduction; 7.2 Nucleosome and SLE; 7.3 Epigenetics and SLE; 7.4 Oxidative stress in SLE: definition and mechanisms; 7.5 Oxidative stress, epigenetic alterations and nucleosome immunogenicity; 7.6 Conclusion; 7.7 Acknowledgements; References; 8 Stress, epigenetics and thyroid autoimmunity; 8.1 Introduction; 8.2 The Th1/Th2 balance in immune-response regulation 327 $a8.3 Stress hormones and the Th1/Th2 balance 330 $aThe role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes:How highly developed epigenetic mechanisms are involved in several aspec 606 $aAutoimmunity$xMolecular aspects 606 $aAutoimmune diseases$xEtiology 606 $aPost-translational modification 606 $aEpigenesis 615 0$aAutoimmunity$xMolecular aspects. 615 0$aAutoimmune diseases$xEtiology. 615 0$aPost-translational modification. 615 0$aEpigenesis. 676 $a571.9/73 676 $a571.973 676 $a616.978042 701 $aZouali$b Moncef$f1952-$01328962 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830763503321 996 $aThe epigenetics of autoimmune diseases$93934138 997 $aUNINA