LEADER 05651nam 2200697Ia 450 001 9910830721503321 005 20230617005258.0 010 $a1-280-23559-4 010 $a9786610235599 010 $a0-470-31848-1 010 $a0-471-74412-3 010 $a0-471-74411-5 035 $a(CKB)1000000000355627 035 $a(EBL)239975 035 $a(OCoLC)475951995 035 $a(SSID)ssj0000122313 035 $a(PQKBManifestationID)11132379 035 $a(PQKBTitleCode)TC0000122313 035 $a(PQKBWorkID)10123460 035 $a(PQKB)11370226 035 $a(MiAaPQ)EBC239975 035 $a(EXLCZ)991000000000355627 100 $a20050411d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCinnolines and phthalazines$b[electronic resource] $esupplement II /$fD.J. Brown 210 $aHoboken, N.J. $cWiley$dc2005 215 $a1 online resource (499 p.) 225 1 $aChemistry of heterocyclic compounds ;$vv. 64 300 $a"Covers both ring systems for the period 1973-2004 with a comprehensive compilation and discussion of the literature"--P. vii. 300 $aContinues a supplemental review by G.M. Singerman and N.R. Patel in: Condensed pyridazines including cinnolines and phthalazines / edited by Raymond N. Castle. 1973. 311 $a0-471-48587-X 320 $aIncludes bibliographical references (p. 413-443) and index. 327 $aCINNOLINES AND PHTHALAZINES Supplement II; Preface; Contents; CHAPTER 1 PRIMARY SYNTHESES OF CINNOLINES; 1.1 From a Single Carbocyclic Substrate; 1.1.1 By Formation of the N1-C8a Bond; 1.1.2 By Formation of the N1-N2 Bond; 1.1.3 By Formation of the N2-C3 Bond; 1.1.4 By Formation of the C3-C4 Bond; 1.1.5 By Formation of the C4-C4a Bond; 1.2 From a Carbocyclic Substrate and One Synthon; 1.2.1 When the Synthon Supplies N2 of the Cinnoline; 1.2.2 When the Synthon Supplies N1 + N2 of the Cinnoline; 1.2.3 When the Synthon Supplies N2 + C3 of the Cinnoline 327 $a1.2.4 When the Synthon Supplies C3 + C4 of the Cinnoline1.2.5 When the Synthon Supplies N1 + N2 + C3 + C4 of the Cinnoline; 1.3 From a Pyridazine Substrate; 1.4 From Other Heteromonocyclic Substrates; 1.5 From Heterobicyclic Substrates; 1.6 From Heteropolycyclic Substrates; 1.7 Glance Index to Typical Cinnolines Derivatives Available by Primary Syntheses; CHAPTER 2 CINNOLINE, ALKYLCINNOLINES, AND ARYLCINNOLINES; 2.1 Cinnoline; 2.1.1 Preparation of Cinnoline and Hydrocinnolines; 2.1.2 Physical Properties of Cinnoline; 2.1.3 Reactions of Cinnoline; 2.2 Alkyl- and Arylcinnolines 327 $a2.2.1 Preparation of Alkyl- and Arylcinnolines2.2.2 Reactions of Alkyl- and Arylcinnolines; CHAPTER 3 HALOGENOCINNOLINES; 3.1 Preparation of Halogenocinnolines; 3.2 Reactions of Halogenocinnolines; CHAPTER 4 OXYCINNOLINES; 4.1 Tautomeric Cinnolinones; 4.1.1 Preparation of Tautomeric Cinnolinones; 4.1.2 Reactions of Tautomeric Cinnolinones; 4.1.2.1 Alkylation of Tautomeric Cinnolinones; 4.1.2.2 Other Reactions of Tautomeric Cinnolinones; 4.2 Other Oxycinnolines; CHAPTER 5 THIOCINNOLINES; 5.1 Cinnolinethiones; 5.2 Other Thiocinnolines; CHAPTER 6 NITRO-, AMINO-, AND RELATED CINNOLINES 327 $a6.1 Nitrocinnolines6.2 Aminocinnolines and Related Compounds; 6.2.1 Preparation of Amino-, Hydrazino-, and Arylazocinnolines; 6.2.2 Reactions of Amino- and Hydrazinocinnolines; CHAPTER 7 CINNOLINECARBOXYLIC ACIDS AND RELATED DERIVATIVES; 7.1 Cinnolinecarboxylic Acids; 7.1.1 Preparation of Cinnolinecarboxylic Acids; 7.1.2 Reactions of Cinnolinecarboxylic Acids; 7.2 Cinnolinecarboxylic Esters; 7.3 Cinnolinecarboxamides and Cinnolinecarbohydrazides; 7.4 Cinnolinecarbonitriles; 7.5 Cinnoline Aldehydes and Ketones; CHAPTER 8 PRIMARY SYNTHESES OF PHTHALAZINES 327 $a8.1 From a Single Benzene Derivative as Substrate8.1.1 By Formation of the C1-C8a Bond; 8.1.2 By Formation of the C1-N2 Bond; 8.2 From a Benzene Derivative as Substrate and One Synthon; 8.2.1 Where the Synthon Supplies C1 of the Phthalazine; 8.2.2 Where the Synthon Supplies N2 + N3 of the Phthalazine; 8.2.2.1 Using 1,2-Dialkylbenzenes as Substrates; 8.2.2.2 Using 1-Alkyl-2-ketobenzenes as Substrates; 8.2.2.3 Using 1-Alkyl-2-halogenoformylbenzenes as Substrates; 8.2.2.4 Using 1,2-Dialdehydrobenzenes as Substrates; 8.2.2.5 Using 1-Aldehydo-2-ketobenzenes as Substrates 327 $a8.2.2.6 Using 1-Aldehydo-2-carboxybenzenes as Substrates 330 $aThis book provides the most comprehensive, current reference on the synthetic chemistry of cinnolines and phthalazines. Applications to the syntheses of natural products and other chiral compounds are described. Volume 64 contains chapters exploring the following topics:* Primary Syntheses of Cinnolines* Cinnoline, Alklycinnolines, and Arylcinnolines* Halogenocinnolines* Oxycinnolines* Thiocinnolines* Nitro-, Amino-, and Related Cinnolines* Cinnolinecarboxylic Acids and Related Derivatives* Primary Syntheses of Phthalazines* Phthalazine, Alklyphthalazines, a 410 0$aChemistry of heterocyclic compounds ;$vv. 64. 606 $aPyridazines 606 $aOrganic compounds$xSynthesis 606 $aChirality 615 0$aPyridazines. 615 0$aOrganic compounds$xSynthesis. 615 0$aChirality. 676 $a547.2 676 $a547.593 700 $aBrown$b D. J$0383088 701 $aCastle$b Raymond N$g(Raymond Nielson),$f1916-$01606444 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830721503321 996 $aCinnolines and phthalazines$93932243 997 $aUNINA