LEADER 03249nam 2200481 450 001 9910822566303321 005 20220519171816.0 010 $a1-4985-5831-3 035 $a(CKB)4340000000261301 035 $a(MiAaPQ)EBC5325403 035 $a(Au-PeEL)EBL5325403 035 $a(CaPaEBR)ebr11532164 035 $a(OCoLC)1021065071 035 $a(EXLCZ)994340000000261301 100 $a20220519d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGender, ethnicity, and violence in Kenya's transitions to democracy $estates of violence /$fby Lyn Ossome 210 1$aLanham, Maryland :$cLexington Books,$d[2018] 210 4$d©2018 215 $a1 online resource (237 pages) 225 1 $aCritical African studies in gender and sexuality 311 $a1-4985-5830-5 320 $aIncludes bibliographical references and index. 327 $aCover -- Gender, Ethnicity, and Violence in Kenya's Transitions to Democracy -- Critical African Studies in Gender and Sexuality -- Gender, Ethnicity, and Violence in Kenya's Transitions to Democracy: States of Violence -- Copyright -- Dedication -- Contents -- Acknowledgments -- Introduction -- Sexual Violence in Kenya's Electoral Context -- Notes -- Chapter 1 -- Violent Challenges to Democracy -- Democracy's Promise and Gendered Limitations of its Liberal Form -- Conceptual Worlds of Sexual Violence -- Ethnicization of Security, Insecurity, and Violence in Kenya (1963-2007) -- Ethnicization of State Security Apparatus (1963-2007) -- Conclusion -- Notes -- Chapter 2 -- Women's Agency in Transition -- Women's Agency and Resistance in the Early Colonial Period -- Notes -- Chapter 3 -- Gendered and Violent Exclusions in Kenya's Multiparty Electoral Politics (1989-2008) -- Gendered Struggles for Political Space and the Politics of Co-optation in the Postcolonial State -- Notes -- Chapter 4 -- Religious Movements and Gendered Violence in the Multiparty Era -- Contemporary Religious Movements in Kenya: Origins and Struggles for Democracy -- Notes -- Chapter 5 -- Women's Organizations and Multiparty Politics in Kenya (1989-2008) -- Setting a Feminist Agenda in Postindependence Kenya -- Notes -- Conclusion -- Feminist Emancipatory Politics under Liberal Democracy -- Notes -- Bibliography -- Index -- About the Author. 330 $aGender, Ethnicity, and Violence in Kenya's Transitions to Democracy examines gendered violence in the context of multiparty politics in Kenya, placing it in the historical milieu of colonial rule and its legacies of the ethnicization of both state and society. 410 0$aCritical African studies in gender and sexuality. 606 $aPolitical violence$zKenya$xHistory 607 $aKenya$xPolitics and government$y1978-2002 607 $aKenya$xPolitics and government$y2002- 615 0$aPolitical violence$xHistory. 676 $a307.1412096762 700 $aOssome$b Lyn$01664516 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910822566303321 996 $aGender, ethnicity, and violence in Kenya's transitions to democracy$94022552 997 $aUNINA LEADER 05192nam 2200625 450 001 9910830717703321 005 20230721033137.0 010 $a1-281-94698-2 010 $a9786611946982 010 $a3-527-62267-5 010 $a3-527-62268-3 035 $a(CKB)1000000000551934 035 $a(EBL)481533 035 $a(OCoLC)277153234 035 $a(SSID)ssj0000112294 035 $a(PQKBManifestationID)11142796 035 $a(PQKBTitleCode)TC0000112294 035 $a(PQKBWorkID)10086817 035 $a(PQKB)10524340 035 $a(MiAaPQ)EBC481533 035 $a(EXLCZ)991000000000551934 100 $a20160819h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiosimulation in drug development /$fedited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff 210 1$aWeinheim, Germany :$cWILEY-VCH Verlag GmbH & Co. KGaA,$d2008. 210 4$d©2008 215 $a1 online resource (542 p.) 300 $aIncludes index. 311 $a3-527-31699-X 327 $aBiosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction 327 $a2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic ?-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 327 $a3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 327 $a3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 327 $a4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 327 $a5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling 330 $aThis first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial dru 606 $aDrug development 606 $aDrug development$xSimulation methods 615 0$aDrug development. 615 0$aDrug development$xSimulation methods. 676 $a615.580724 702 $aBertau$b Martin 702 $aMosekilde$b Erik 702 $aWesterhoff$b Hans V. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830717703321 996 $aBiosimulation in drug development$93932722 997 $aUNINA LEADER 01973nam 2200409z- 450 001 9910476885003321 005 20210416 035 $a(CKB)5470000000567107 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/64633 035 $a(oapen)doab64633 035 $a(EXLCZ)995470000000567107 100 $a20202104d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSyntax of Hungarian$ePostpositions and Postpositional Phrases 210 $cAmsterdam University Press$d2021 215 $a1 online resource (481 p.) 225 1 $aComprehensive Grammar Resources 311 08$a94-6372-591-1 330 $aThe Syntax of Hungarian aims to present a synthesis of the currently available syntactic knowledge of the Hungarian language, rooted in theory but providing highly detailed descriptions, and intended to be of use to researchers, as well as advanced students of language and linguistics. 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