LEADER 05101nam 2200685 a 450 001 9910830711803321 005 20170815095340.0 010 $a1-118-39714-2 010 $a1-299-24138-7 010 $a1-118-39720-7 010 $a1-118-39716-9 035 $a(CKB)2670000000327573 035 $a(EBL)1120452 035 $a(OCoLC)827207814 035 $a(SSID)ssj0000831933 035 $a(PQKBManifestationID)11966394 035 $a(PQKBTitleCode)TC0000831933 035 $a(PQKBWorkID)10882209 035 $a(PQKB)11204381 035 $a(MiAaPQ)EBC1120452 035 $a(DLC) 2012028721 035 $a(PPN)19449702X 035 $a(EXLCZ)992670000000327573 100 $a20120713d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aInhalation drug delivery$b[electronic resource] $etechniques and products /$fPaolo Colombo, Daniela Traini, Francesca Buttini 210 $aChichester, West Sussex, U.K. $cWiley-Blackwell$d2013 215 $a1 online resource (215 p.) 225 1 $aPostgraduate Pharmacy Series 225 0$aULLA postgraduate pharmacy series 300 $aDescription based upon print version of record. 311 $a1-118-35412-5 320 $aIncludes bibliographical references and index. 327 $aInhalation Drug Delivery: Techniques and Products; Contents; List of contributors; Series foreword; Preface; 1 Inhalation drug delivery; 1.1 Introduction; 1.2 Brief review of the respiratory system and its physiology; 1.3 Deposition and the fate of particles in the respiratory tract; 1.4 Deposition mechanisms; 1.5 Parameters influencing particle deposition; 1.6 The clearance of deposited particles; 1.7 Airways geometry and humidity; 1.8 Lung clearance mechanisms; 1.9 Local and systemic drug delivery; 1.10 Conclusion; References; 2 Inhalation and nasal products; 2.1 Introduction 327 $a2.2 Dry powder inhalers (DPIs)2.3 Liquid and propellant-based inhalers; 2.3.1 Pressurized metered-dose inhalers (pMDIs); 2.3.2 Nebulizers; 2.4 Nasal formulations; 2.4.1 Nasal physiology; 2.4.2 Delivery issues and concerns; 2.4.3 Strategy for enhanced nasal delivery; 2.4.4 Marketed nasal products; 2.4.5 Pharmaceutical development studies for nasal products; 2.5 Conclusion; References; 3 Formulation of inhalation medicines; 3.1 Introduction; 3.2 Pressurized metered-dose inhaler (pMDI) formulation; 3.2.1 Suspension technology; 3.2.2 Solution technology; 3.3 Dry powder inhaler (DPI) formulation 327 $a3.3.1 Carrier technology3.3.2 Agglomerate technology; 3.4 Conclusion; References; 4 Novel particle production technologies for inhalation products; 4.1 Introduction; 4.2 Conventional crystallization and milling; 4.3 Specialized milling; 4.3.1 Fluid-energy milling at elevated humidity; 4.3.2 Wet-milling nanotechnology; 4.4 Solvent precipitation; 4.4.1 Sono-crystallization; 4.4.2 Microprecipitation by opposing liquid jets and tangential liquid jets; 4.4.3 High-gravity controlled precipitation; 4.5 Spray-drying and related droplet evaporation methods; 4.5.1 Spray-drying 327 $a4.5.2 Controlled evaporation of droplets4.5.3 Evaporation of low-boiling-point solutions; 4.5.4 Spray freeze-drying; 4.6 Supercritical fluid (SCF) technology; 4.7 Conclusion; Acknowledgements; References; 5 Methods for understanding, controlling, predicting, and improving drug product performance; 5.1 Introduction; 5.1.1 The complexities and challenges of aerosol performance; 5.1.2 Understanding powder/particle characteristics: implications for aerosol product performance; 5.1.3 Liquid systems; 5.1.4 Summary; 5.2 Particle sizing; 5.2.1 Sieve analysis; 5.2.2 Image analysis; 5.2.3 Light scatter 327 $a5.2.4 Time-of-flight5.2.5 Other methods; 5.3 Powder and particulate characterization systems; 5.3.1 Introduction; 5.3.2 Powder cohesion and adhesion; 5.3.3 Microscopic material characterization; 5.3.4 Methods for studying bulk powders; 5.4 Practical issues in process control; 5.4.1 Common primary and secondary processing methods and issues arising for control; 5.5 Biopharmaceutical powder stability; 5.6 Liquids: solutions and suspensions; 5.6.1 Liquid formulation stability; 5.7 Conclusion; References 327 $a6 Aerodynamic assessment for inhalation products: fundamentals and current pharmacopoeial methods 330 $a"Provides students and those in industry with concise clear guide to the essential fundamentals in inhalation drug delivery"--Provided by publisher. 410 0$aPostgraduate Pharmacy Series 606 $aRespiratory therapy 606 $aDrug delivery systems$xMethodology 615 0$aRespiratory therapy. 615 0$aDrug delivery systems$xMethodology. 676 $a615.6 700 $aColombo$b Paolo$f1944-$0313280 701 $aTraini$b Daniela$01606727 701 $aButtini$b Francesca$01606728 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830711803321 996 $aInhalation drug delivery$93932676 997 $aUNINA