LEADER 04082nam 2200601Ia 450 001 9910830686103321 005 20170814191054.0 010 $a1-282-68958-4 010 $a9786612689581 010 $a0-470-68626-X 010 $a0-470-68670-7 035 $a(CKB)2550000000012498 035 $a(EBL)516964 035 $a(OCoLC)612432913 035 $a(SSID)ssj0000426524 035 $a(PQKBManifestationID)11257655 035 $a(PQKBTitleCode)TC0000426524 035 $a(PQKBWorkID)10389264 035 $a(PQKB)10229591 035 $a(MiAaPQ)EBC516964 035 $a(PPN)149878869 035 $a(EXLCZ)992550000000012498 100 $a20091113d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aQuantitative modeling in toxicology$b[electronic resource] /$feditors, Kannan Krishnan, Melvin E. Andersen 210 $aChichester, West Sussex ;$aHoboken $cJohn Wiley & Sons$d2010 215 $a1 online resource (505 p.) 300 $aDescription based upon print version of record. 311 $a0-470-99809-1 320 $aIncludes bibliographical references and index. 327 $aQuantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition 327 $a7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 327 $a15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index 330 $aGovernments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter desc 606 $aToxicology$xMathematical models 606 $aBiological models 615 0$aToxicology$xMathematical models. 615 0$aBiological models. 676 $a615.90015118 676 $a615.907 701 $aKrishnan$b Kannan$f1961-$01604373 701 $aAndersen$b Melvin E$01604374 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830686103321 996 $aQuantitative modeling in toxicology$93929171 997 $aUNINA